03 February 2021 : Clinical Research
U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study
Hao You1ABCE, Kegong Chen2BCE, Pengfei Han3C, ChaoFu Yue4B, Xia Zhao5ADEG*DOI: 10.12659/MSM.928937
Med Sci Monit 2021; 27:e928937
Supplementary Table 3 Stratification analysis by race/ethnicity.
Uric acid, mg/dl | White (n=7,378) | p Value | Non-white (n=7,781) | p Value |
---|---|---|---|---|
HR (95% CI) | HR (95% CI) | |||
All-cause mortality | ||||
≤3.5 | 1.82 (1.25–2.65) | 0.002 | 0.69 (0.47–1.02) | 0.064 |
3.5–5.0 | 1.19 (1.03–1.37) | 0.018 | 0.89 (0.71–1.12) | 0.316 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 1.11 (0.94–1.31) | 0.204 | 1.03 (0.85–1.24) | 0.798 |
>7.5 | 1.42 (1.17–1.72) | 0.000 | 1.17 (0.90–1.5) | 0.237 |
CVD mortality* | ||||
≤3.5 | 2.91 (1.62–5.22) | 0.001 | 0.53 (0.16–1.77) | 0.296 |
3.5–5.0 | 1.53 (1.02–2.28) | 0.039 | 0.58 (0.32–1.08) | 0.083 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 1.24 (0.88–1.74) | 0.216 | 0.94 (0.56–1.57) | 0.814 |
>7.5 | 1.63 (1.08–2.47) | 0.022 | 0.72 (0.37–1.38) | 0.317 |
Heart-related mortality | ||||
≤3.5 | 2.01 (1.07–3.77) | 0.029 | 0.32 (0.11–0.90) | 0.031 |
3.5–5.0 | 1.41 (0.97–2.06) | 0.072 | 0.59 (0.33–1.07) | 0.080 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 1.19 (0.86–1.67) | 0.294 | 1.06 (0.67–1.68) | 0.810 |
>7.5 | 1.65 (1.16–2.34) | 0.006 | 0.95 (0.56–1.61) | 0.847 |
Stroke mortality* | ||||
≤3.5 | 5.53 (1.79–17.1) | 0.004 | 2.01 (0.42–9.75) | 0.379 |
3.5–5.0 | 1.44 (0.75–2.78) | 0.268 | 0.95 (0.21–4.35) | 0.945 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 1.7 (0.76–3.79) | 0.191 | 0.67 (0.17–2.58) | 0.554 |
>7.5 | 1.6 (0.55–4.72) | 0.383 | 0.78 (0.17–3.58) | 0.747 |
Cancer mortality | ||||
≤3.5 | 1.76 (0.84–3.68) | 0.133 | 1.62 (0.86–3.06) | 0.136 |
3.5–5.0 | 1.04 (0.71–1.52) | 0.842 | 1.07 (0.71–1.60) | 0.753 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 1.17 (0.81–1.69) | 0.412 | 1.00 (0.63–1.59) | 0.999 |
>7.5 | 1.30 (0.80–2.13) | 0.284 | 1.23 (0.77–1.99) | 0.381 |