03 February 2021 : Clinical Research
U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study
Hao You1ABCE, Kegong Chen2BCE, Pengfei Han3C, ChaoFu Yue4B, Xia Zhao5ADEG*DOI: 10.12659/MSM.928937
Med Sci Monit 2021; 27:e928937
Supplementary Table 4 Stratification analysis by BMI.
| Uric acid, mg/dl | BMI <30 (n=8,396) | p Value | BMI ≥30 (n=7,150) | p Value |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| All-cause mortality | ||||
| ≤3.5 | 1.41 (1.02–1.94) | 0.035 | 2.05 (1.29–3.26) | 0.003 |
| 3.5–5.0 | 1.08 (0.94–1.24) | 0.280 | 1.22 (0.94–1.58) | 0.129 |
| 5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
| 6.0–7.5 | 1.13 (0.96–1.33) | 0.152 | 1.01 (0.81–1.25) | 0.948 |
| >7.5 | 1.43 (1.20–1.70) | 0.000 | 1.23 (0.93–1.63) | 0.142 |
| CVD mortality* | 1 (ref.) | 1 (ref.) | ||
| ≤3.5 | 2.42 (1.25–4.66) | 0.009 | 1.37 (0.30–6.32) | 0.682 |
| 3.5–5.0 | 1.29 (0.86–1.95) | 0.213 | 1.46 (0.79–2.68) | 0.220 |
| 5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
| 6.0–7.5 | 1.34 (0.92–1.94) | 0.123 | 0.94 (0.62–1.43) | 0.768 |
| >7.5 | 1.24 (0.75–2.05) | 0.397 | 1.51 (0.80–2.84) | 0.197 |
| Heart-related mortality | 1 (ref.) | 1 (ref.) | ||
| ≤3.5 | 1.67 (0.90–3.09) | 0.105 | 1.57 (0.46–5.35) | 0.467 |
| 3.5–5.0 | 1.22 (0.85–1.73) | 0.275 | 1.43 (0.77–2.68) | 0.259 |
| 5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
| 6.0–7.5 | 1.32 (0.94–1.86) | 0.112 | 0.97 (0.66–1.44) | 0.896 |
| >7.5 | 1.17 (0.74–1.84) | 0.494 | 1.74 (1.02–2.99) | 0.044 |
| Stroke mortality* | 1 (ref.) | 1 (ref.) | ||
| ≤3.5 | 4.24 (1.46–12.34) | 0.009 | 5.74 (0.60–54.82) | 0.126 |
| 3.5–5.0 | 1.28 (0.62–2.63) | 0.498 | 0.77 (0.27–2.22) | 0.620 |
| 5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
| 6.0–7.5 | 1.17 (0.51–2.67) | 0.706 | 1.07 (0.38–2.95) | 0.901 |
| >7.5 | 1.71 (0.58–5.06) | 0.326 | 0.99 (0.25–3.84) | 0.985 |
| Cancer mortality | 1 (ref.) | 1 (ref.) | ||
| ≤3.5 | 1.48 (0.71–3.12) | 0.295 | 2.88 (1.41–5.86) | 0.004 |
| 3.5–5.0 | 1.06 (0.75–1.49) | 0.736 | 1.06 (0.66–1.70) | 0.810 |
| 5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
| 6.0–7.5 | 1.09 (0.79–1.50) | 0.611 | 1.10 (0.64–1.89) | 0.721 |
| >7.5 | 1.45 (0.96–2.20) | 0.076 | 1.01 (0.57–1.78) | 0.972 |