03 February 2021 : Clinical Research
U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study
Hao You1ABCE, Kegong Chen2BCE, Pengfei Han3C, ChaoFu Yue4B, Xia Zhao5ADEG*DOI: 10.12659/MSM.928937
Med Sci Monit 2021; 27:e928937
Supplementary Table 5 Stratification analysis by age groups.
Uric acid, mg/dl | Age <65y (n=8,716) | p Value | Age ≥65y (n=6,443) | p Value |
---|---|---|---|---|
HR (95% CI) | HR (95% CI) | |||
All-cause mortality | ||||
≤3.5 | 1.32 (0.75–2.31) | 0.333 | 1.55 (1.07–2.26) | 0.021 |
3.5–5.0 | 0.90 (0.67–1.22) | 0.502 | 1.27 (1.08–1.49) | 0.003 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 0.90 (0.70–1.16) | 0.422 | 1.17 (0.99–1.39) | 0.071 |
>7.5 | 1.27 (0.91–1.78) | 0.165 | 1.30 (1.10–1.54) | 0.003 |
CVD mortality* | ||||
≤3.5 | 1.70 (0.41–7.05) | 0.456 | 2.01 (0.98–4.11) | 0.056 |
3.5–5.0 | 0.98 (0.45–2.12) | 0.959 | 1.44 (0.92–2.24) | 0.107 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 0.94 (0.53–1.66) | 0.822 | 1.31 (0.93–1.84) | 0.124 |
>7.5 | 1.64 (0.73–3.67) | 0.225 | 1.15 (0.80–1.64) | 0.453 |
Heart-related mortality | ||||
≤3.5 | 0.88 (0.13–5.86) | 0.893 | 1.46 (0.74–2.89) | 0.275 |
3.5–5.0 | 1.32 (0.65–2.66) | 0.436 | 1.16 (0.78–1.73) | 0.455 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 1.41 (0.81–2.46) | 0.221 | 1.15 (0.82–1.61) | 0.422 |
>7.5 | 2.43 (1.15–5.14) | 0.020 | 1.21 (0.85–1.73) | 0.293 |
Stroke mortality* | ||||
≤3.5 | 11.2 (1.80–69.68) | 0.010 | 3.69 (1.34–10.21) | 0.013 |
3.5–5.0 | 1.03 (0.12–8.58) | 0.976 | 1.50 (0.84–2.70) | 0.167 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 0.37 (0.06–2.37) | 0.286 | 1.52 (0.73–3.19) | 0.262 |
>7.5 | 0.93 (0.14–6.42) | 0.943 | 1.12 (0.39–3.18) | 0.836 |
Cancer mortality | ||||
≤3.5 | 2.47 (1.23–4.98) | 0.012 | 1.07 (0.46–2.51) | 0.877 |
3.5–5.0 | 0.96 (0.52–1.77) | 0.897 | 1.11 (0.79–1.55) | 0.549 |
5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
6.0–7.5 | 1.06 (0.61–1.85) | 0.835 | 1.08 (0.81–1.44) | 0.596 |
>7.5 | 1.19 (0.64–2.20) | 0.575 | 1.13 (0.73–1.74) | 0.586 |