03 February 2021 : Clinical Research
U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study
Hao You1ABCE, Kegong Chen2BCE, Pengfei Han3C, ChaoFu Yue4B, Xia Zhao5ADEG*DOI: 10.12659/MSM.928937
Med Sci Monit 2021; 27:e928937
Supplementary Table 6 Stratification analysis by anti-hypertension medications.
| Uric acid, mg/dl | Non-antihypertension agents (n=5,671) | p Value | Anti-hypertension (n=9,488) | p Value |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| All-cause mortality | ||||
| ≤3.5 | 0.90 (0.53–1.53) | 0.688 | 1.91 (1.38–2.62) | 0.000 |
| 3.5–5.0 | 0.85 (0.68–1.07) | 0.163 | 1.26 (1.08–1.47) | 0.004 |
| 5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
| 6.0–7.5 | 0.9 (0.68–1.18) | 0.427 | 1.17 (1.01–1.34) | 0.031 |
| >7.5 | 1.19 (0.85–1.66) | 0.314 | 1.41 (1.18–1.69) | 0.000 |
| CVD mortality* | 1 (ref.) | 1 (ref.) | ||
| ≤3.5 | 0.85 (0.32–2.24) | 0.734 | 2.87 (1.47–5.58) | 0.002 |
| 3.5–5.0 | 0.65 (0.38–1.13) | 0.126 | 1.60 (1.05–2.44) | 0.029 |
| 5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
| 6.0–7.5 | 0.71 (0.38–1.31) | 0.265 | 1.41 (1.00–1.99) | 0.047 |
| >7.5 | 1.40 (0.61–3.2) | 0.417 | 1.52 (1.01–2.31) | 0.046 |
| Heart-related mortality | 1 (ref.) | 1 (ref.) | ||
| ≤3.5 | 1.40 (0.57–3.45) | 0.461 | 1.17 (0.55–2.51) | 0.675 |
| 3.5–5.0 | 0.79 (0.41–1.52) | 0.484 | 1.28 (0.88–1.87) | 0.191 |
| 5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
| 6.0–7.5 | 1.10 (0.62–1.97) | 0.738 | 1.23 (0.90–1.69) | 0.194 |
| >7.5 | 1.62 (0.6–4.34) | 0.337 | 1.56 (1.10–2.23) | 0.014 |
| Stroke mortality* | 1 (ref.) | 1 (ref.) | ||
| ≤3.5 | 0.38 (0.04–4.06) | 0.419 | 15.92 (5.41–46.88) | 0.000 |
| 3.5–5.0 | 0.38 (0.11–1.35) | 0.131 | 3.50 (1.60–7.65) | 0.002 |
| 5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
| 6.0–7.5 | 0.21 (0.06–0.68) | 0.011 | 3.54 (1.58–7.96) | 0.003 |
| >7.5 | 0.91 (0.20–4.08) | 0.903 | 2.70 (1.02–7.10) | 0.045 |
| Cancer mortality | 1 (ref.) | 1 (ref.) | ||
| ≤3.5 | 1.51 (0.59–3.89) | 0.39 | 1.85 (0.87–3.90) | 0.107 |
| 3.5–5.0 | 1.17 (0.71–1.94) | 0.54 | 0.94 (0.61–1.46) | 0.796 |
| 5.0–6.0 | 1 (ref.) | 1 (ref.) | ||
| 6.0–7.5 | 1.05 (0.61–1.82) | 0.851 | 1.13 (0.79–1.62) | 0.506 |
| >7.5 | 0.71 (0.28–1.81) | 0.471 | 1.39 (0.87–2.20) | 0.163 |