03 February 2021 : Clinical Research
U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study
Hao You1ABCE, Kegong Chen2BCE, Pengfei Han3C, ChaoFu Yue4B, Xia Zhao5ADEG*DOI: 10.12659/MSM.928937
Med Sci Monit 2021; 27:e928937
Supplementary Table 7 Repeated analysis after adjustment for C-reactive protein in NHANES 1999–2006.
Uric acid, mg/dl | HR (95% CI) | p Value |
---|---|---|
All-cause mortality | ||
≤3.5 | 1.51 (0.99–2.31) | 0.055 |
3.5–5.0 | 1.17 (0.99–1.38) | 0.064 |
5.0–6.0 | 1.00 (ref.) | |
6.0–7.5 | 1.17 (0.99–1.39) | 0.057 |
>7.5 | 1.42 (1.16–1.74) | 0.001 |
Heart-related mortality | ||
≤3.5 | 1.18 (0.54–2.56) | 0.676 |
3.5–5.0 | 1.24 (0.82–1.86) | 0.306 |
5.0–6.0 | 1.00 (ref.) | |
6.0–7.5 | 1.16 (0.85–1.57) | 0.343 |
>7.5 | 1.38 (0.97–1.96) | 0.071 |
Cancer mortality | ||
≤3.5 | 2.15 (1.07–4.34) | 0.033 |
3.5–5.0 | 1.14 (0.81–1.61) | 0.451 |
5.0–6.0 | 1.00 (ref.) | |
6.0–7.5 | 1.3 (0.90–1.89) | 0.158 |
>7.5 | 1.41 (0.87–2.28) | 0.165 |
CVD mortality** | ||
≤3.5 | 1.93 (1.08–3.44) | 0.027 |
3.5–5.0 | 1.26 (0.88–1.81) | 0.204 |
5.0–6.0 | 1.00 (ref.) | |
6.0–7.5 | 1.19 (0.91–1.54) | 0.193 |
>7.5 | 1.36 (0.98–1.87) | 0.062 |
Stroke mortality** | ||
≤3.5 | 4.31 (1.64–11.31) | 0.004 |
3.5–5.0 | 1.29 (0.70–2.38) | 0.413 |
5.0–6.0 | 1.00 (ref.) | |
6.0–7.5 | 1.31 (0.67–2.55) | 0.426 |
>7.5 | 1.25 (0.53–2.96) | 0.599 |
** Estimated in NHANES 1999–2006. Hazard ratio (95% confidence interval) was estimated via weighted cox regression analysis after adjustment for age (years, continuous), sex (female or male), race/ethnicity (non-Hispanic white, black, Hispanic-Mexican, or other), poverty to income ratio ( |