04 March 2021 : Database Analysis
Identification of Biomarkers Based on Bioinformatics Analysis: The Expression of Ubiquitin-Conjugating Enzyme E2T (UBE2T) in the Carcinogenesis and Progression of Hepatocellular Carcinoma
Xuemiao Zhao1ABEF, Wei Weng2ACDE, Miao Jin3CD, Sunjian Li4AB, Qingwei Chen5EF, Bingrong Li2BC, Zhou Zhou6BC, Chuanqiang Lan2BE, Yunjun Yang1AEF*DOI: 10.12659/MSM.929023
Med Sci Monit 2021; 27:e929023
Table 3 Functional roles of 16 hub genes with degree ≥10.
| Gene symbol | Full name | Function |
|---|---|---|
| UBE2T | Ubiquitin-conjugating enzyme E2 T | Catalyzes the covalent attachment of ubiquitin to protein substrates |
| HABP2 | Hyaluronan binding protein 2 | Encodes a member of the peptidase S1 family of serine proteases |
| MT1M | Metallothionein 1M | Encodes a member of the metallothionein superfamily, type 1 family |
| CFP | Complement factor properdin | Encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system |
| ENO3 | Enolase 3 | Encodes 1 of the 3 enolase isoenzymes found in vertebrates |
| CYP2C18 | Cytochrome P450 family 2 subfamily C member 18 | Encodes a member of the cytochrome P450 superfamily of enzymes. |
| CCL2 | C-C motif chemokine ligand 2 | 1 of several cytokine genes clustered on the q-arm of chromosome 17 |
| FBLN5 | Fibulin 5 | Protein encoded is a secreted, extracellular matrix protein containing an Arg-Gly-Asp motif and calcium-binding EGF-like domains |
| KMO | Kynurenine 3-monooxygenase | Encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine |
| ACMSD | Aminocarboxymuconate semialdehyde decarboxylase | Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde to alpha-aminomuconate semialdehyde |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 | Encodes an enzyme that is a member of the prostaglandin G/H synthase family |
| CLEC1B | C-type lectin domain family 1, member b | CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells |