Clinical Application of Chromosomal Microarray Analysis in Pregnant Women with Advanced Maternal Age and Fetuses with Ultrasonographic Soft Markers

10 April 2021 : Clinical Research

Zhu-Ming Hu^1ABCE, Lei-Lei Li^1ABD, Han Zhang^1BF, Hong-Guo Zhang^1BC, Rui-Zhi Liu^1AFG, Yang Yu^1ACF*

DOI: 10.12659/MSM.929074

Med Sci Monit 2021; 27:e929074

Background Material and Methods Results Discussion Conclusions References

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Table 6 Summary of detection rate of clinically significant CMA findings in AMA women and fetal USG soft markers in the literature.

References	AMA		Fetal abnormal soft markers			AMA and Fetal abnormal soft markers
References	Number of cases	Detection rate of Clinical significant (%)	Soft marker	Number of cases	Detection rate of Clinical significant (%)	Number of cases	Detection rate of Clinical significant (%)
Wapner RJ, et al []⁷	1966	34 (1.73)	N.R.	N.R.	N.R.	N.R.	N.R.
Shaffer LG, et al []¹⁶	346	1 (0.29)	All	77	2 (2.6)	N.R.	N.R.
FiorentinoF, et al []¹⁷	439	3 (0.68)	N.R.	N.R.	N.R.	N.R.	N.R.
Scott F, et al []¹⁸	393	2 (0.51)	N.R.	N.R.	N.R.	N.R.	N.R.
Konialis C, et al []¹⁹	2107	9 (0.43)	N.R.	N.R.	N.R.	N.R.	N.R.
Papoulidis I, et al []²⁰	574	2 (0.35)	Increased NT	160	1 (0.63)	N.R.	N.R.
Van Opstal D, et al []²¹	624	5 (0.80)	N.R.	N.R.	N.R.	N.R.	N.R.
Li L, et al []²²	N.R.	N.R.	Thickened NF	65	5 (7.69)	N.R.	N.R.
Su L, et al []⁹	N.R.	N.R.	Increased NT	174	5 (2.87)	N.R.	N.R.
Sagi-Dain L, et al []²³	2318	23 (0.99)	All	239	7 (2.93)	N.R.	N.R.
Song TT, et al []²⁴	N.R.	N.R.	All	404	20 (4.95)	N.R.	N.R.
Wu X, et al []¹⁴	437	4 (0.92)	N.R.	N.R.	N.R.	134	2 (1.49)
Present study	633	15 (2.37)	All	750	15 (2.0)	138	7 (5.07)
CMA – chromosomal microarray analysis; AMA – advanced maternal age; NT – nuchal translucency; NF – nuchal fold; N.R. – no reported.

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