08 April 2021>: Review Articles
Current Status of MicroRNAs that Target the Wnt Signaling Pathway in Regulation of Osteogenesis and Bone Metabolism: A Review
Qiang Sun AEF , Siyu Liu CD , Jingyi Feng CE , Yue Kang BD , You Zhou E , Shu Guo A*DOI: 10.12659/MSM.929510
Med Sci Monit 2021; 27:e929510
Table 1 The role of miRNAs in osteogenesis by regulating the Wnt signaling pathway.
MiRNAs | Relative expression | Biological function | Targets | References |
---|---|---|---|---|
MiR-218 | Up | Inhibit type 1 collagen generation | COL1A1 | []29 |
MiR-218 | Up | Inhibit ADAMTS2 | TIMP3 | []29 |
MiR-218 | Up | Inhibit RUNX2 | Runx2 | [,]29 |
MiR-218 | Up | Promote osteogenesis of MSCs | []32 | |
MiR-218 | Down | Promote osteogenesis (wnt/β-catenin pathway) | Sost | []35 |
MiR-218 | Down | Promote osteogenesis (wnt/β-catenin pathway) | Dkk2 | []35 |
MiR-218 | Down | Promote osteogenesis (wnt/β-catenin pathway) | SFRP2 | []35 |
MiR-218 | Up | Activate wnt/β-catenin pathway | β-catenin | []36 |
MiR-218 | Up | Activate wnt/β-catenin pathway | P-FZD | []36 |
MiR-218 | Up | Activate wnt signaling pathway | PPP2R5A | []37 |
MiR-335-5p | Up | Inhibit wnt/β-catenin pathway | APC | []40 |
MiR-335-5p | Up | Inhibit wnt/β-catenin pathway | AXIN-1 | []40 |
MiR-335-5p | Up | Activate wnt/β-catenin pathway | Dkk-1 | []42 |
MiR-335 | Up | Promote proliferation, migration and differentiation | GSK-3β | []41 |
MiR-335 | Up | Promote proliferation, migration and differentiation | β-catenin | []41 |
MiR-335 | Up | Promote osteogenesis | Runx2 | []43 |
MiR-335 | Up | Inhibit EMT | Twist1 | []44 |
MiR-335 | Up | Inhibit wnt/β-catenin pathway | Wnt3a,Wnt5a | []44 |
MiR-29 | Up | Promote osteogenesis | GSK-3β | [,]45 |
MiR-29a | Up | Inhibit wnt/β-catenin pathway | LRP6 | []49 |
MiR-29b1 | Up | Inhibit wnt/β-catenin pathway | CTNNB1 | []49 |
MiR-29 | Up | Inhibit wnt/β-catenin pathway | DKK-1 | [,,]45 |
MiR-29 | Up | Inhibit wnt signaling pathway | KREMEN2 | [,,]45 |
MiR-29 | Up | Inhibit wnt/β-catenin pathway | SFRP2 | [,,]45 |
MiR-29 | Up | Inhibit wnt/β-catenin pathway | GSK-3β | []52 |
MiR-29 | Up | Inhibit wnt signaling pathway | ICAT/CTNNBIP1 | []52 |
MiR-29 | Up | Inhibit wnt signaling pathway | HBP1 | []52 |
MiR-29 | Up | Inhibit wnt signaling pathway | GLIS2 | []52 |
MiR-29 | Up | Inhibit wnt/β-catenin pathway | Wnt3a | [,]55 |
MiR-29 | Up | Promote osteogenesis | Osteonectin | []38 |
MiR-29-a | Up | Promote osteoblast formation | Osteonectin | []38 |
MiR-29c | Up | Promote osteoblast formation | Osteonectin | []57 |
MiR-30s | Up | Wnt/Ca2+ pathway | CamkII delta | []60 |
MiR-30c | Up | Wnt/Ca2+ pathway | CamkII delta | []60 |
MiR-30e | Up | Inhibit proliferation and migration | β-catenin | [,]58 |
MiR-30c | Up | Inhibit wnt/β-catenin pathway | BCL9 | [–]61 |
MiR-376c | Up | Inhibit wnt/β-catenin pathway | Wnt3a | []67 |
MiR-16-2-3p | Up | Inhibit wnt/Ca2+ pathway | Wnt5a | []69 |
MiR-154-5p | Up | Inhibit Planar cell Polarity pathway | Wnt11 | []21 |
MiR-139-5p | Up | Inhibit wnt signaling pathway | FZD4 | []70 |
MiR-210-3p | Up | Inhibit wnt/β-catenin pathway | LRP5 | []72 |
MiR-376c | Up | Inhibit wnt signaling pathway | ARF-GEF-1 | []67 |
MiR-139-5p | Up | Inhibit wnt signaling pathway | CTNNB1 | []70 |
MiR-210-3p | Up | activate wnt/β-catenin pathway | GSK-3β | []72 |
MiR-210-3p | Up | activate wnt/β-catenin pathway | β-catenin | []72 |
MiR-210-3p | Up | activate wnt/β-catenin pathway | TCF4 | []72 |
MiR-124 | Up | activate wnt/β-catenin pathway | GSk-3β | []73 |
MiR-135b | Up | Promote metastasis and recurrence of sarcoma | GSK-β | []74 |
MiR-135b | Up | Promote metastasis and recurrence of sarcoma | TET3 | []74 |
MiR-135b | Up | Promote metastasis and recurrence of sarcoma | CKLA | []74 |
MiR-142-3p | Up | Activate wnt/β-catenin pathway | APC | []75 |
MiR-141 | Up | Inhibit wnt/β-catenin pathway | β-catenin | []76 |
MiR-22 | Up | Inhibit wnt/β-catenin pathway | β-catenin | []76 |