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08 April 2021: Review Articles

Current Status of MicroRNAs that Target the Wnt Signaling Pathway in Regulation of Osteogenesis and Bone Metabolism: A Review

Qiang Sun AEF , Siyu Liu CD , Jingyi Feng CE , Yue Kang BD , You Zhou E , Shu Guo A*

DOI: 10.12659/MSM.929510

Med Sci Monit 2021; 27:e929510

Table 1 The role of miRNAs in osteogenesis by regulating the Wnt signaling pathway.

MiRNAsRelative expressionBiological functionTargetsReferences
MiR-218UpInhibit type 1 collagen generationCOL1A1[]29
MiR-218UpInhibit ADAMTS2TIMP3[]29
MiR-218UpInhibit RUNX2Runx2[,]29
MiR-218UpPromote osteogenesis of MSCs[]32
MiR-218DownPromote osteogenesis (wnt/β-catenin pathway)Sost[]35
MiR-218DownPromote osteogenesis (wnt/β-catenin pathway)Dkk2[]35
MiR-218DownPromote osteogenesis (wnt/β-catenin pathway)SFRP2[]35
MiR-218UpActivate wnt/β-catenin pathwayβ-catenin[]36
MiR-218UpActivate wnt/β-catenin pathwayP-FZD[]36
MiR-218UpActivate wnt signaling pathwayPPP2R5A[]37
MiR-335-5pUpInhibit wnt/β-catenin pathwayAPC[]40
MiR-335-5pUpInhibit wnt/β-catenin pathwayAXIN-1[]40
MiR-335-5pUpActivate wnt/β-catenin pathwayDkk-1[]42
MiR-335UpPromote proliferation, migration and differentiationGSK-3β[]41
MiR-335UpPromote proliferation, migration and differentiationβ-catenin[]41
MiR-335UpPromote osteogenesisRunx2[]43
MiR-335UpInhibit EMTTwist1[]44
MiR-335UpInhibit wnt/β-catenin pathwayWnt3a,Wnt5a[]44
MiR-29UpPromote osteogenesisGSK-3β[,]45
MiR-29aUpInhibit wnt/β-catenin pathwayLRP6[]49
MiR-29b1UpInhibit wnt/β-catenin pathwayCTNNB1[]49
MiR-29UpInhibit wnt/β-catenin pathwayDKK-1[,,]45
MiR-29UpInhibit wnt signaling pathwayKREMEN2[,,]45
MiR-29UpInhibit wnt/β-catenin pathwaySFRP2[,,]45
MiR-29UpInhibit wnt/β-catenin pathwayGSK-3β[]52
MiR-29UpInhibit wnt signaling pathwayICAT/CTNNBIP1[]52
MiR-29UpInhibit wnt signaling pathwayHBP1[]52
MiR-29UpInhibit wnt signaling pathwayGLIS2[]52
MiR-29UpInhibit wnt/β-catenin pathwayWnt3a[,]55
MiR-29UpPromote osteogenesisOsteonectin[]38
MiR-29-aUpPromote osteoblast formationOsteonectin[]38
MiR-29cUpPromote osteoblast formationOsteonectin[]57
MiR-30sUpWnt/Ca2+ pathwayCamkII delta[]60
MiR-30cUpWnt/Ca2+ pathwayCamkII delta[]60
MiR-30eUpInhibit proliferation and migrationβ-catenin[,]58
MiR-30cUpInhibit wnt/β-catenin pathwayBCL9[–]61
MiR-376cUpInhibit wnt/β-catenin pathwayWnt3a[]67
MiR-16-2-3pUpInhibit wnt/Ca2+ pathwayWnt5a[]69
MiR-154-5pUpInhibit Planar cell Polarity pathwayWnt11[]21
MiR-139-5pUpInhibit wnt signaling pathwayFZD4[]70
MiR-210-3pUpInhibit wnt/β-catenin pathwayLRP5[]72
MiR-376cUpInhibit wnt signaling pathwayARF-GEF-1[]67
MiR-139-5pUpInhibit wnt signaling pathwayCTNNB1[]70
MiR-210-3pUpactivate wnt/β-catenin pathwayGSK-3β[]72
MiR-210-3pUpactivate wnt/β-catenin pathwayβ-catenin[]72
MiR-210-3pUpactivate wnt/β-catenin pathwayTCF4[]72
MiR-124Upactivate wnt/β-catenin pathwayGSk-3β[]73
MiR-135bUpPromote metastasis and recurrence of sarcomaGSK-β[]74
MiR-135bUpPromote metastasis and recurrence of sarcomaTET3[]74
MiR-135bUpPromote metastasis and recurrence of sarcomaCKLA[]74
MiR-142-3pUpActivate wnt/β-catenin pathwayAPC[]75
MiR-141UpInhibit wnt/β-catenin pathwayβ-catenin[]76
MiR-22UpInhibit wnt/β-catenin pathwayβ-catenin[]76

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750