05 August 2021 : Database Analysis
N6-Methyladenosine Regulators Are Involved in the Progression of and Have Clinical Impact on Breast Cancer
Yanni Song12BCEFG, Chaojing Zheng3C, Yangbao Tao3D, Rui Huang3E, Qian Zhang4AE*DOI: 10.12659/MSM.929615
Med Sci Monit 2021; 27:e929615
Table 1 Cox regression analysis of risk scores and clinicopathological factors for patients’ overall survival.
| Characteristics | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | |
| Age (≥62 vs <62 years) | 2.01 (1.77–2.27) | <0.001 | 2.02 (1.73–2.37) | <0.001 |
| Risk score (high vs low) | 1.48 (1.32–1.67) | <0.001 | 1.23 (1.08–1.39) | 0.002 |
| Hormone therapy (yes vs no) | 1.28 (1.13–1.44) | <0.001 | 0.93 (0.79–1.09) | 0.372 |
| Chemotherapy (yes vs no) | 1.23 (1.06–1.43) | 0.007 | 1.14 (0.91–1.42) | 0.261 |
| Radiotherapy (yes vs no) | 0.84 (0.74–0.94) | 0.003 | 0.78 (0.68–0.89) | <0.001 |
| Histologic grade | ||||
| 1 | 1 | 1 | ||
| 2 | 1.28 (1–1.64) | 0.046 | 1.07 (0.69–1.67) | 0.764 |
| 3 | 1.63 (1.28–2.07) | <0.001 | 0.96 (0.56–1.64) | 0.878 |
| ER Status (positive vs negative) | 0.85 (0.74–0.98) | 0.022 | 0.91 (0.74–1.11) | 0.347 |
| PR Status (positive vs negative) | 0.79 (0.7–0.89) | <0.001 | 0.9 (0.78–1.04) | 0.169 |
| HER2 Status (positive vs negative) | 1.45 (1.22–1.73) | <0.001 | 1.36 (1.13–1.65) | 0.001 |
| Menopausal State (pre vs post) | 0.59 (0.5–0.7) | <0.001 | 0.87 (0.71–1.07) | 0.192 |
| Tumor Laterality (right vs left) | 0.93 (0.82–1.05) | 0.252 | ||
| NPI | ||||
| ≤2.4 | 1 | 1 | ||
| (2.4–3.4] | 0.97 (0.75–1.24) | 0.787 | 0.87 (0.52–1.46) | 0.609 |
| (3.4–5.4] | 1.39 (1.1–1.74) | 0.005 | 1.14 (0.6–2.16) | 0.688 |
| ≥5.4 | 3.07 (2.35–4.01) | <0.001 | 1.51 (0.65–3.51) | 0.337 |
| No. of positive LN | ||||
| 0 | 1 | 1 | ||
| 1–3 | 1.36 (1.19–1.56) | <0.001 | 1.21 (0.98–1.5) | 0.076 |
| 4–9 | 2.14 (1.78–2.58) | <0.001 | 1.51 (1.03–2.2) | 0.034 |
| ≥10 | 4.27 (3.38–5.38) | <0.001 | 2.48 (1.62–3.79) | <0.001 |
| Tumor Size (>23 vs ≤23) | 1.86 (1.65–2.1) | <0.001 | 1.53 (1.35–1.75) | <0.001 |
| CI – confidence interval; ER – estrogen receptor; HER2 – human epidermal growth factor receptor 2; HR – hazard ratio; LN – lymph node; NPI – Nottingham prognostic index; PR – progesterone receptor. | ||||