15 March 2021 : Laboratory Research
Long Noncoding RNA TCONS_00068220 Promotes Breast Cancer Progression by Regulating Epithelial-Mesenchymal Transition Marker E-Cadherin
Xiao Liu12ABEF, Xingsong Tian1ACDG*DOI: 10.12659/MSM.929832
Med Sci Monit 2021; 27:e929832
Table 1 The correlation between TCONS_00068220 expression level and clinicopathological features of breast cancer patients.
| Characteristics | TCONS_00068220 level | P-value | ||
|---|---|---|---|---|
| High (n, %) | Low (n, %) | |||
| Age (years) | ≥50 | 19 (63.3) | 24 (80.0) | 0.153 |
| <50 | 11 (36.7) | 6 (20.0) | ||
| Her-2 | Negative | 21 (70.0) | 19 (63.3) | 0.239 |
| Positive | 9 (30.0) | 11 (36.7) | ||
| TNBC | TNBC | 18 (60.0) | 17 (56.7) | 0.135 |
| Non-TNBC | 12 (40.0) | 13 (43.3) | ||
| Ki67 | High index | 25 (83.3) | 16 (53.3) | 0.042 |
| Low index | 5 (16.7) | 14 (46.7) | ||
| Lymphatic metastasis | Negative | 6 (20.0) | 19 (63.3) | 0.000 |
| Positive | 24 (80.0) | 11 (36.7) | ||
| Differentiation status | Well/moderate | 7 (23.3) | 18 (60.0) | 0.012 |
| Poor | 23 (76.7) | 12 (40.0) | ||
| TNM stage | I–II | 20 (66.7) | 13 (43.3) | 0.014 |
| III–IV | 10 (33.3) | 17 (56.7) | ||
| TNBC – triple-negative breast cancer; TNM – tumor, node, metastasis. | ||||