05 April 2021 : Clinical Research
Effects of Different Exposure Days to Gonadotropin-Releasing Hormone Agonist (GnRH-a) on Live Birth Rates in the Depot GnRH-a Protocol: A Retrospective Analysis of 7007 Cycles
Jianyuan Song1ABCDEFG, Wei Wu1BC, Liu Jiang2CD, Cuicui Duan3BC, Jian Xu1AG*DOI: 10.12659/MSM.929854
Med Sci Monit 2021; 27:e929854
Table 2 Ovarian stimulation data.
| Exposure days to GnRH-a before ovarian stimulation | ||||
|---|---|---|---|---|
| ≤30 | 31–35 | ≥36 | P | |
| Number of patients | 2001 | 2824 | 2182 | |
| Duration of stimulation (days) | 10.9±2.0 | 11.2±2.0 | 11.4±2.0 | 0.000 |
| Gn dose (IU) | 2368.6 | 2431.8 | 2492.1 | 0.000 |
| Estradiol (pg/ml) | 2259.2 | 2399.5 | 2514.7 | 0.000 |
| Progesterone (ng/ml) | 0.7±0.3 | 0.8±0.4 | 0.8±0.4 | 0.000 |
| LH (mIU/ml) | 0.9±0.5 | 0.9±0.5 | 0.9±0.8 | 0.926 |
| Endometrial thickness | 12.2±2.6 | 12.1±2.6 | 12.1±2.5 | 0.149 |
| Number of oocytes retrieved | 12.9±4.9 | 13..1±4.8 | 13.3±4.9 | 0.021 |
| Type of treatment | 0.962 | |||
| IVF | 1273 (63.6%) | 1788 (63.3%) | 1389 (63.7%) | |
| ICSI | 728 (36.4%) | 1036 (36.7%) | 793 (36.3%) | |
| Number of 2PN | 7.5±3.8 | 7.9±3.8 | 8.0±3.7 | 0.005 |
| Number of embryo transfer | 0.616 | |||
| 1 | 1364 (68.2%) | 1961 (69.4%) | 1511 (69.2%) | |
| 2 | 637 (31.8%) | 863 (30.6%) | 671 (30.8%) | |
| Number of blastocyst frozen | 2.5±2.5 | 2.7±2.5 | 2.7±2.5 | 0.022 |
| Data are expressed as mean±SD or number (percentage). Gn – Gonadotropin; LH – luteinizing hormone; PN – two visualized pronuclei; IVF – in vitro fertilization and embryo transfer; ICSI – intracytoplasmic sperm injection. | ||||