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03 May 2021: Meta-Analysis

The Roles of Reduced Folate Carrier-1 (RFC1) A80G (rs1051266) Polymorphism in Congenital Heart Disease: A Meta-Analysis

Kang Yi 12ABCDEF* , Yu-Hu Ma 23ABCDEF* , Wei Wang 23BCF , Xin Zhang 24BCF , Jie Gao 23BCD , Shao-E He 25BCD , Xiao-Min Xu 23CDF , Meng Ji 23CDF , Wen-Fen Guo 6ADEG* , Tao You 12ABCDEFG*

DOI: 10.12659/MSM.929911

Med Sci Monit 2021; 27:e929911

Table 1 Characteristics of included studies.

First authorYearCountryRegionGenotyping methodCase typeControls sourcePHWE
Wang BJ []27 2013ChinaEast AsianSNaPShot multiple PCRCHDHB0.142
Shaw GM []19 2003USANorth AmericaPCR-RFLPCHDPB0.0085
Gong DX []28 2012ChinaEast AsianMALDI-ToF-MSTOF, TGAHB0.189
Pei LJ []29 2006ChinaEast AsianPCR-RFLPCHDPB0.9
Koshy T []30 2015IndiaSouth AsianABI 3730 automated sequencerCTDPB0.00036
Wang XK []18 2018ChinaEast AsianTaqman SNP Genotyping AssayCTDHB0.0000584
Pei LJ []29 2006ChinaEast AsianPCR-RFLPCHDPB0.601
CHD – congenital heart disease; HWE – Hardy Weinberge quilibrium; NA – notavailable; TGA – transposition of the great arteries; TOF – tetralogy of fallot; PB – population-based; HB – hospital-based; CTD – conotruncal heart defects.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750