03 May 2021 : Meta-Analysis
The Roles of Reduced Folate Carrier-1 (RFC1) A80G (rs1051266) Polymorphism in Congenital Heart Disease: A Meta-Analysis
Kang Yi12ABCDEF, Yu-Hu Ma23ABCDEF, Wei Wang23BCF, Xin Zhang24BCF, Jie Gao34BCD, Shao-E He25BCD, Xiao-Min Xu23CDF, Meng Ji23CDF, Wen-Fen Guo6ADEG, Tao You12ABCDEFG*DOI: 10.12659/MSM.929911
Med Sci Monit 2021; 27:e929911
Table 4 Meta-analysis of reduced folate carrier-1 (RFC1) A80G polymorphism and fetal congenital heart disease risk.
| Type | OR (95%CI) | z | P | Test of heterogeneity | Analysis model | |
|---|---|---|---|---|---|---|
| I2 | p* | |||||
| GA VS GG | 1.36 [1.06, 1.75] | 2.4 | 0.02 | 0 | 0.51 | Fixed-effects model |
| AA VS GG | 0.99 [0.74, 1.34] | 0.04 | 0.97 | 11 | 0.34 | Fixed-effects model |
| GA+AA VS GG | 1.24 [0.98, 1.57] | 1.79 | 0.07 | 0 | 0.58 | Fixed-effects model |
| AA VS GG+GA | 0.83 [0.65, 1.06] | 1.52 | 0.13 | 38 | 0.17 | Fixed-effects model |
| A VS G | 1.02 [0.88, 1.18] | 0.21 | 0.84 | 9 | 0.36 | Fixed-effects model |
| GA VS GG | 1.33 [0.98, 1.79] | 1.84 | 0.07 | 5 | 0.37 | Fixed-effects model |
| AA VS GG | 1.16 [0.83, 1.64] | 0.87 | 0.39 | 0 | 0.69 | Fixed-effects model |
| GA+AA VS GG | 1.29 [0.97, 1.70] | 1.78 | 0.08 | 0 | 0.45 | Fixed-effects model |
| AA VS GG+GA | 0.97 [0.73, 1.29] | 0.19 | 0.85 | 0 | 0.66 | Fixed-effects model |
| A VS G | 1.09 [0.92, 1.30] | 0.98 | 0.32 | 0 | 0.57 | Fixed-effects model |