Association of High-Mobility Group Box 1 (HMGB1) Gene Polymorphisms with Susceptibility and Better Survival Prognosis in Chinese Han Neonatal Necrotizing Enterocolitis

Huiling Cao; Defeng Guo

doi:10.12659/MSM.930015

31 May 2021 : Clinical Research

Association of High-Mobility Group Box 1 (HMGB1) Gene Polymorphisms with Susceptibility and Better Survival Prognosis in Chinese Han Neonatal Necrotizing Enterocolitis

Huiling Cao^1ABCEF, Defeng Guo^2CEF*

DOI: 10.12659/MSM.930015

Med Sci Monit 2021; 27:e930015

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Table 4 Multivariate logistic regression analysis for the factors that independently predict survival outcomes in necrotizing enterocolitis (NEC) patients.

Factors	OR	95% CI	P value
Metabolic acidosis	18.941	6.766–53.024	<0.001
Respiratory distress syndrome	1.447	0.579–3.615	0.429
Neonatal scleredema	2.990	0.874–10.223	0.081
Intestinal perforation	21.464	5.923–77.774	<0.001
Diffuse peritonitis	6.732	2.410–18.809	<0.001
Thrombocytopenia	7.171	2.631–19.549	<0.001
Leukocyte disorder	1.424	0.589–3.443	0.433
rs1360485 genotypes TC+CC	0.306	0.111–0.844	0.022

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Association of High-Mobility Group Box 1 (HMGB1) Gene Polymorphisms with Susceptibility and Better Survival Prognosis in Chinese Han Neonatal Necrotizing Enterocolitis

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