22 May 2021 : Clinical Research
Association of Lymphocyte-to-Monocyte Ratio with Poststroke Depression in Patients with Acute Ischemic Stroke
Lining Chong1ACDF, Lin Han2ABDF, Ruqian Liu1BDF, Guomei Ma1BF, Hao Ren1ABCDEF*DOI: 10.12659/MSM.930076
Med Sci Monit 2021; 27:e930076
Table 3 Clinical and demographic characteristics of patients with poststroke depression (PSD) and without PSD.
| Variables | Non-PSD patients (n=366) | Mild PSD patients (n=117) | Moderate to severe PSD patients (n=24) | p-Value |
|---|---|---|---|---|
| Age(years), median (IQR) | 60.0 (54.0–70.3) | 68.0 (56.0–77.0) | 71.0 (60.0–80.3) | 0.285 |
| Gender (Male), n (%) | 255 (69.7) | 71 (60.7) | 12 (50.0) | 0.040 |
| Marital status (married), n(%) | 363 (99.2) | 115 (98.3) | 22 (91.7) | 0.134 |
| Admission to hospital (hours), median (IQR) | 15.8 (5.0–41.0) | 14.0 (6.0–42.5) | 12.0 (4.5–24.8) | 0.763 |
| Education (years), median (IQR) | 8.0 (6.0–11.0) | 8.0 (7.0–11.0) | 8.5 (6.3–10.8) | 0.973 |
| LMR, median (IQR) | 4.46 (2.90–5.68) | 2.65 (1.43–4.04) | 1.07 (0.92–2.98) | <0.001 |
| Tertile 1 (>4.85), n (%) | 145 (39.6) | 22 (18.8) | 2 (8.3) | <0.001 |
| Tertile 2 (2.96–4.85), n (%) | 127 (34.7) | 35 (29.9) | 7 (29.2) | 0.574 |
| Tertile 3 (<2.96), n (%) | 94 (25.7) | 60 (51.3) | 15 (62.5) | <0.001 |
| Smoking, n (%) | 190 (51.9) | 56 (47.9) | 6 (25.0) | 0.035 |
| Alcohol drinking, n (%) | 168 (45.9) | 48 (41.0) | 8 (33.3) | 0.358 |
| Hypertension, n (%) | 289 (79.0) | 83 (70.9) | 19 (79.2) | 0.193 |
| Diabetes, n (%) | 95 (26.0) | 27 (23.1) | 3 (12.5) | 0.301 |
| Hyperlipidemia, n (%) | 135 (36.9) | 43 (36.8) | 8 (33.3) | 0.941 |
| AF, n (%) | 31 (8.5) | 13 (11.1) | 2 (8.3) | 0.693 |
| CHD, n (%) | 86 (23.5) | 34 (29.1) | 6 (25.0) | 0.480 |
| Stroke history, n (%) | 117 (32.0) | 46 (39.3) | 10 (41.7) | 0.251 |
| Frontal lobe, n (%) | 39 (10.7) | 43 (36.8) | 7 (29.2) | <0.001 |
| Parietal lobe, n (%) | 34 (9.3) | 7 (6.0) | 3 (12.5) | 0.430 |
| Temporal lobe, n (%) | 15 (4.1) | 11 (9.4) | 8 (33.3) | <0.001 |
| Occipital lobe, n (%) | 19 (5.2) | 5 (4.3) | 2 (8.3) | 0.710 |
| Basal ganglia, n (%) | 135 (36.9) | 66 (56.4) | 10 (41.7) | 0.001 |
| Midbrain, n (%) | 29 (7.9) | 8 (6.8) | 3 (12.5) | 0.584 |
| Pons, n (%) | 37 (10.1) | 9 (7.7) | 4 (16.7) | 0.366 |
| Medulla, n (%) | 31 (8.5) | 10 (8.5) | 3 (12.5) | 0.671 |
| Cerebellum, n (%) | 34 (9.3) | 12 (10.3) | 5 (20.8) | 0.170 |
| CRP (mg/L) | 10.21±2.12 | 10.52±1.86 | 10.83±3.10 | 0.510 |
| ESR (mm/h) | 12.51±1.98 | 12.76±3.28 | 13.66±2.95 | 0.189 |
| PCT (ng/ml) | 1.26±0.36 | 1.42±0.41 | 1.66±0.33 | 0.141 |
| NIHSS score, median (IQR) | 3.0 (1.0–5.0) | 8.0 (5.0–11.5) | 10.0 (7.5–12.8) | <0.001 |
| HAMD score, median (IQR) | 1.0 (0–3.0) | 12.0 (9.0–15.0) | 19.0 (18.0–20.0) | <0.001 |
| PSD – post-stroke depression; n – number of patients; AF – atrial fibrillation; CHD – coronary heart disease; CRP – C-reactive protein; ESR – erythrocyte sedimentation rate; PCT – procalcitonin; NIHSS – National Institutes of Health Stroke Scale; HAMD – Hamilton Depression Scale; LMR – lymphocyte-to-monocyte ratio. | ||||