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07 February 2021: Review Articles

A Review of the Current Practice of Diagnosis and Treatment of Idiopathic Membranous Nephropathy in China

Lianzhong Wu 12AE* , Jin Lai 12B* , Yixin Ling 12C , Yiqin Weng 12B , Shujuan Zhou 1D , Siqi Wu 2D , Songfu Jiang 1D , Xiaokai Ding 3D , Xin Jin 4EFG* , Kang Yu 1EF* , Yi Chen 1EF*

DOI: 10.12659/MSM.930097

Med Sci Monit 2021; 27:e930097

Table 1 Recent advances and remaining challenges in the diagnosis and treatment of idiopathic membranous nephropathy in China.

Current advancesRemaining challenges
Anti-PLAR detection is used widelyGenetic differences and disease susceptibility
THSD7A was identified as a second antigen to facilitate diagnosisEnvironmental factors and disease susceptibility
EXT1/EXT2 proteins may represent biomarkers for MN associated with autoimmune diseaseThe physiological roles of PLAR and THSD7A
Progress related to the complement systemThe mechanisms of podocyte injury induced by IgG4 anti-PLAR and anti-THSD7A
Rituximab therapyDefining the pathogenicity of complement and CRPs
CRPs – complement and complement regulatory proteins; EXT1/EXT2 – exostosin1/exostosin2; MN – membranous nephropathy; PLAR – phospholipase A receptor; THSD7A – thrombospondin type-1 domain-containing 7A.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750