23 August 2021: Meta-Analysis
Periodontitis and Number of Teeth in the Risk of Coronary Heart Disease: An Updated Meta-Analysis
Shuting Gao 1BEF , Jinhui Tian 2A , Yiting Li 1CD , Tingjie Liu 1B , Ruiping Li 1C , Lan Yang 3FG* , Zhankui Xing 1AG*DOI: 10.12659/MSM.930112
Med Sci Monit 2021; 27:e930112
Table 4 Hazard ratio (HR) or risk ratio (RR) of included studies sorted by adjustment factors in meta-analysis with subgroup as number of teeth.
| Reference | Subgroup | Tooth count | HR/RR | CI | Adjustment |
|---|---|---|---|---|---|
| 24-17 | Remain tooth | 1.08 | 0.88–1.33 | Age, smoking | |
| 16-11 | 1.12 | 0.76–1.64 | |||
| 10-06 | 1.4 | 1.04–1.87 | |||
| 24-17 | 1.04 | 0.85–1.28 | Age; BMI; exercise; smoking habits; alcohol consumption; family history of MI before 60 years of age; VEc | ||
| 16-11 | 1.06 | 0.72–1.56 | |||
| 10-0 | 1.32 | 0.98–1.77 | |||
| 24-17 | 1.03 | 0.83–1.27 | Multivariate+dietd | ||
| 16-11 | 1.04 | 0.71–1.54 | |||
| 10-0 | 1.29 | 0.96–1.73 | |||
| 24-17 | Remain tooth | 0.84 | 0.64–1.09 | Multivariate$ | |
| 16-11 | 0.75 | 0.51–1.10 | |||
| 10-4 | 0.88 | 0.62–1.25 | |||
| 24-17 (man)a | Remain tooth | 1.15 | 1.00–1.32 | Age, smoking | |
| 16-11 | 1.41 | 1.11–1.80 | |||
| 10-0 | 1.49 | 1.22–1.83 | |||
| 24-17 (woman)a | 1.28 | 1.03–1.60 | |||
| 16-11 | 1.6 | 1.15–2.22 | |||
| 10-0 | 2.13 | 1.70–2.65 | |||
| 24-17 (man)a | 1.1 | 0.95–1.26 | Age, smoking, alcohol consumption, BMI, physical activity, family history of MI, multivitamin supplement, VE, hypertension, diabetes, hormone use, hypercholesterolemia in both cohorts and professions for men only, menopausal status | ||
| 16-11 | 1.35 | 1.06–1.72 | |||
| 10-0 | 1.36 | 1.11–1.67 | |||
| 24-17 (man)b | 1.26 | 1.01–1.57 | |||
| 16-11 | 1.19 | 0.79–1.80 | |||
| 10-0 | 1.79 | 1.34–2.40 | |||
| 24-17 (woman)a | 1.14 | 0.92–1.42 | |||
| 16-11 | 1.34 | 0.97–1.87 | |||
| 10-0 | 1.64 | 1.31–2.05 | |||
| 24-17 (woman)b | 1.02 | 0.66–1.55 | |||
| 16-11 | 1.07 | 0.56–2.05 | |||
| 10-0 | 1.65 | 1.11–2.46 | |||
| 25-20 | Remain tooth | 1.94 | 1.17–3.21 | Age, gender, and smoking | |
| 19-15 | 3.45 | 2.04–5.84 | |||
| 14-10 | 3.3 | 1.82–5.99 | |||
| 7.33 | 4.11–13.07 | ||||
| 2–4 | Tooth loss | 1.22 | 0.81–1.85 | Age, sex, smoking, geographic variable, systolic blood pressure, blood pressure treatment, cholesterol, HDL cholesterol, education, existing diabetes | |
| 5–8 | 1.62 | 1.08–2.43 | |||
| 9–31 | 1.99 | 1.37–2.89 | |||
| 32 | 1.65 | 1.09–2.50 | |||
| a Coronary heart disease (CHD) incidence: symptomatic nonfatal myocardial infarction (MI), fatal CHD, or sudden death. b CHD mortality. c Age (continuous); body mass index (5 categories); exercise (5 categories); smoking habits (current smoker [number of cigarettes smoked: 1–14, 15–24, 25+], former smoker, or never smoked); alcohol consumption (7 categories); family history of myocardial infarction before 60 years of age; vitamin E (5 categories). d Dietary variables include dietary fiber and carrots. $ Indicates demographics and socioeconomic status, including age, sex, race, poverty index, and also cardiovascular risk factors (smoking, cigarettes, blood pressure, cholesterol, diabetes, height, physical activity). HDL – high-density lipoprotein; VE – vitamin E. | |||||