Periodontitis and Number of Teeth in the Risk of Coronary Heart Disease: An Updated Meta-Analysis

Shuting Gao; Jinhui Tian; Yiting Li; Tingjie Liu; Ruiping Li; Lan Yang; Zhankui Xing

doi:10.12659/MSM.930112

23 August 2021 : Meta-Analysis

Periodontitis and Number of Teeth in the Risk of Coronary Heart Disease: An Updated Meta-Analysis

Shuting Gao^1BEF, Jinhui Tian^2A, Yiting Li^1CD, Tingjie Liu^1B, Ruiping Li^1C, Lan Yang^3FG, Zhankui Xing^1AG*

DOI: 10.12659/MSM.930112

Med Sci Monit 2021; 27:e930112

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Table 4 Hazard ratio (HR) or risk ratio (RR) of included studies sorted by adjustment factors in meta-analysis with subgroup as number of teeth.

Reference	Subgroup	Tooth count	HR/RR	CI	Adjustment
	24-17	Remain tooth	1.08	0.88–1.33	Age, smoking
	16-11		1.12	0.76–1.64
	10-06		1.4	1.04–1.87

	24-17		1.04	0.85–1.28	Age; BMI; exercise; smoking habits; alcohol consumption; family history of MI before 60 years of age; VEc
	16-11		1.06	0.72–1.56
	10-0		1.32	0.98–1.77

	24-17		1.03	0.83–1.27	Multivariate+diet^d
	16-11		1.04	0.71–1.54
	10-0		1.29	0.96–1.73

	24-17	Remain tooth	0.84	0.64–1.09	Multivariate^$
	16-11		0.75	0.51–1.10
	10-4		0.88	0.62–1.25

	24-17 (man)^a	Remain tooth	1.15	1.00–1.32	Age, smoking
	16-11		1.41	1.11–1.80
	10-0		1.49	1.22–1.83
	24-17 (woman)^a		1.28	1.03–1.60
	16-11		1.6	1.15–2.22
	10-0		2.13	1.70–2.65

	24-17 (man)^a		1.1	0.95–1.26	Age, smoking, alcohol consumption, BMI, physical activity, family history of MI, multivitamin supplement, VE, hypertension, diabetes, hormone use, hypercholesterolemia in both cohorts and professions for men only, menopausal status
	16-11		1.35	1.06–1.72
	10-0		1.36	1.11–1.67
	24-17 (man)^b		1.26	1.01–1.57
	16-11		1.19	0.79–1.80
	10-0		1.79	1.34–2.40
	24-17 (woman)^a		1.14	0.92–1.42
	16-11		1.34	0.97–1.87
	10-0		1.64	1.31–2.05
	24-17 (woman)^b		1.02	0.66–1.55
	16-11		1.07	0.56–2.05
	10-0		1.65	1.11–2.46

	25-20	Remain tooth	1.94	1.17–3.21	Age, gender, and smoking
	19-15		3.45	2.04–5.84
	14-10		3.3	1.82–5.99
	<10		7.33	4.11–13.07

	2–4	Tooth loss	1.22	0.81–1.85	Age, sex, smoking, geographic variable, systolic blood pressure, blood pressure treatment, cholesterol, HDL cholesterol, education, existing diabetes
	5–8		1.62	1.08–2.43
	9–31		1.99	1.37–2.89
	32		1.65	1.09–2.50
^a Coronary heart disease (CHD) incidence: symptomatic nonfatal myocardial infarction (MI), fatal CHD, or sudden death. ^b CHD mortality. ^c Age (continuous); body mass index (5 categories); exercise (5 categories); smoking habits (current smoker [number of cigarettes smoked: 1–14, 15–24, 25+], former smoker, or never smoked); alcohol consumption (7 categories); family history of myocardial infarction before 60 years of age; vitamin E (5 categories). ^d Dietary variables include dietary fiber and carrots. ^$ Indicates demographics and socioeconomic status, including age, sex, race, poverty index, and also cardiovascular risk factors (smoking, cigarettes, blood pressure, cholesterol, diabetes, height, physical activity). HDL – high-density lipoprotein; VE – vitamin E.

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Periodontitis and Number of Teeth in the Risk of Coronary Heart Disease: An Updated Meta-Analysis

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