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01 April 2021 : Animal Research  

Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics and Network Pharmacology

Feiya Jiang1AE, Tongtong Wang1B, Sha Li2D, Yu Jiang3C, Zhuo Chen4F, Wen Liu1AG*

DOI: 10.12659/MSM.930166

Med Sci Monit 2021; 27:e930166

Table 1 Identification of significantly different metabolites from control, PQ, and PQ+AKF-PD groups by UPLC-QTOF-MS.

Nom/zMetaboliteFormulaVIPFold change (control/PQ)Fold change (PQ+ AKF-PD/PQ)Pathway involved
1134.09Malic acidC4H6O51.130742.5447 1.6942↓* Amino sugar and nucleotide sugar metabolism
2208.21L-KynurenineC10H12N2O31.118081.41978 0.61965 Tyrosine metabolism
3307.33GlutathioneC10H17N3O6S1.034630.0584↓* 2.2952 Glutathione metabolism
4495.33LysoPC160CHNOP1.187421.8909 1.5564 Glycerophospholipid metabolism
5250.29Ubiquinone-1C14H18O41.149041.8712 1.8611
6282.5Oleic acidC18H34O21.184121.5532 0.48813↓* Biosynthesis of unsaturated fatty acids
795.979Phosphoric acidHO4P-21.092840.5675↓* 0.82607↓*
8284.4RetinalC20H28O1.171260.5198↓* 1.5389 Retinol metabolism
9276.146-Phosphogluconic acidC6H13O10P1.642931.514↓* 0.2113↓* Pentose phosphate pathway
10204.22TryptophanC11H12N2O21.343190.1111↓* 1.3933 Tryptophan metabolism
11310.511Z-Eicosenoic acidC20H38O21.402420.1408↓* 1.3846 Biosynthesis of unsaturated fatty acids
12302.5Retinyl esterC20H30O21.171260.359↓* 1.2502↓* Retinol metabolism
13280.4Linoleic acidC18H32O21.316380.2517↓* 1.97377 Linoleic acid metabolism
14476.6Retinoyl b-glucuronideC26H36O81.171260.2505↓* 0.0379↓* Retinol metabolism
15180.16D-GalactoseC6H12O61.092841.2251 0.97158↓* Galactose metabolism
16130.1Citraconic acidC5H6O41.04321.135↓* 0.937↓* Tricarboxylic acid cycle
17178.21CysteinylglycineC5H10N2O3S1.472940.96835↓* 1.01868 Cysteine and methionine metabolism
18188.23Homo-L-arginineC7H16N4O21.444821.0304 0.7317↓* Arginine metabolism
* The values were statistically significant (p
↑ The metabolites were up-regulated; ↓ The metabolites were down-regulated.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750