13 April 2021 : Clinical Research
Intrahepatic Cholestasis of Pregnancy Is Associated with Reduced Nitric Oxide Synthase (iNOS) in Plasma and Placentas: A Pilot Study
Yun Wang1G, Liping Zhu1D, Duo Xu2F, Liying Gao1C, Yongmei Li1E, Baoquan Liang1BC, Xiaoqian Zhang1B, Yongfei Yue1AC*DOI: 10.12659/MSM.930176
Med Sci Monit 2021; 27:e930176
Table 1 Clinical characteristics of women with intrahepatic cholestasis of pregnancy (ICP) and normal pregnancies.
| Parameter (mean±SD) | Normal (n=80) | ICP (n=77) | p-Value |
|---|---|---|---|
| Age at delivery (years) | 28.97±4.43 | 28.62±4.48 | NS |
| BMI before pregnancy (kg/m) | 26.35±2.27 | 24.81±3.29 | NS |
| Gravidity | 1.96±1.07 | 2.05±1.06 | NS |
| Parity | 1.30±0.46 | 1.24±0.43 | NS |
| GA at delivery (week) | 38.70±1.31 | 37.21±1.47 | p<0.001 |
| TBA (μmol/L) | 6.89±1.82 | 29.71±19.04 | p<0.001 |
| CG (μmol/L) | 9.40±3.95 | 27.50±18.20 | p<0.001 |
| ALT (U/L) | 28.19±10.24 | 72.90±67.09 | p<0.001 |
| AST (U/L) | 24.35±12.57 | 84.22±70.07 | p<0.001 |
| TB (μmol/L) | 9.09±3.43 | 14.88±7.44 | p<0.001 |
| CB (μmol/L) | 2.51±1.90 | 4.45±3.62 | p<0.001 |
| UCB (μmol/L) | 6.65±2.32 | 10.40±4.76 | p<0.001 |
| TC | 4.30±1.30 | 5.97±1.68 | p<0.001 |
| TG | 2.21±1.03 | 3.12±1.32 | p<0.001 |
| iNOS (pg/ml) | 3073.77±457.16 | 2337.70±483.46 | p<0.001 |
| Rate of caesarean section | 18.75% | 48.05% | p<0.001 |
| Birth weight (g) | 3386.97±412.03 | 3120.10±413.52 | p<0.001 |
| Placnetal weight (g) | 518.99±61.42 | 478.44±77.23 | p<0.001 |
| 1 min | 10 (10, 10) | 9 (9, 10) | p<0.001 |
| 5 min | 10 (10, 10) | 9 (9, 10) | p<0.001 |
| FIUD | 3.75% | 12.99% | 0.034 |
| Preterm delivery | 5.00% | 16.88% | 0.021 |
| IUGR | 3.75% | 14.29% | 0.025 |
| Neonatal unit admission | 8.75% | 16.56% | 0.009 |
| BMI – body mass index; GA – Gestational age; TBA – total bile acid; CG – Cholyglycine, ALT – alanine transaminase; AST – aspartate transaminase; TB – total bilirubin; CB – conjugated bilirubin; UCB – unconjugated bilirubin; TC – total cholesterol; TG – triglyceridel FIUD – fetal distress in uterus; IUGR – intrauterine growth retardation. Results are expressed as mean±standard error of the mean. APGAR Scores were expressed as median (interquartile range). | |||