Intrahepatic Cholestasis of Pregnancy Is Associated with Reduced Nitric Oxide Synthase (iNOS) in Plasma and Placentas: A Pilot Study

13 April 2021 : Clinical Research

Yun Wang^1G, Liping Zhu^1D, Duo Xu^2F, Liying Gao^1C, Yongmei Li^1E, Baoquan Liang^1BC, Xiaoqian Zhang^1B, Yongfei Yue^1AC*

DOI: 10.12659/MSM.930176

Med Sci Monit 2021; 27:e930176

Background Material and Methods Results Discussion Conclusions References

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Table 2 Bivariate correlation between inducible nitric oxide synthase (iNOS) levels and other variables.

iNOS	Normal		ICP
	r	p-Value	r	p-Value
Age at delivery (years)	0.029	p<0.001	0.085	p<0.001
BMI before pregnancy (kg/m)	−0.040	p<0.001	0.066	p<0.001
Gravidity	0.145	p<0.001	0.083	p<0.001
Parity	0.028	p<0.001	0.172	p<0.001
GA at delivery (week)	−0.157	p<0.001	0.046	p<0.001
TBA (μmol/L)	−0.227	p<0.001	−0.514	p<0.001
CG (μmol/L)	−0.204	p<0.001	−0.437	p<0.001
ALT (U/L)	−0.273	p<0.001	−0.327	p<0.001
AST (U/L)	−0.324	p<0.001	−0.432	p<0.001
TB (μmol/L)	−0.122	p<0.001	−0.101	p<0.001
CB (μmol/L)	−0.223	p<0.001	−0.029	p<0.001
UCB (μmol/L)	−0.005	0.021	−0.137	p<0.001
TC (mmol/L)	0.032	p<0.001	−0.049	p<0.001
TG (mmol/L)	−0.150	p<0.001	−0.008	p<0.001
Birth weight (g)	0.286	p<0.001	0.176	p<0.001
Placnetal weight (g)	0.214	p<0.001	0.246	p<0.001

1 min	0.121	p<0.001	0.204	p<0.001
5 min	0.313	p<0.001	0.196	p<0.001
BMI – body mass index; GA – gestational age; TBA – total bile acid, CG – cholyglycine; ALT – alanine transaminase; AST – aspartate transaminase; TB – total bilirubin; TG – triglyceride; TC – total cholesterol; CB – conjugated bilirubin; UCB – unconjugated bilirubin.

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