Intrahepatic Cholestasis of Pregnancy Is Associated with Reduced Nitric Oxide Synthase (iNOS) in Plasma and Placentas: A Pilot Study

13 April 2021 : Clinical Research

Yun Wang^1G, Liping Zhu^1D, Duo Xu^2F, Liying Gao^1C, Yongmei Li^1E, Baoquan Liang^1BC, Xiaoqian Zhang^1B, Yongfei Yue^1AC*

DOI: 10.12659/MSM.930176

Med Sci Monit 2021; 27:e930176

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Table 3 Multivariate linear regression analysis between total bile acid (TBA) and clinical characteristics.

Variable	β (95% confidence interval)	SE	p-Value
Age at delivery(years)	−0.034 (−0.041 to−0.026)	0.004	0.203
BMI before pregnancy(kg/m)	0.589 (0.577 to 0.601)	0.006	0.063
Gravidity	1.557 (1.521 to 1.592)	0.018	0.201
Parity	−1.790 (−1.876 to −1.704)	0.044	0.161
GA at delivery (week)	−1.608 (−1.632 to −1.584)	0.012	0.072
CG (μmol/L)	0.435 (0.432 to 0.437)	0.001	p<0.001
ALT (U/L)	0.092 (0.091 to 0.093)	0.001	p<0.001
AST (U/L)	0.064 (0.063 to 0.065)	0.001	p<0.001
TB (μmol/L)	1.326 (1.231 to 1.420)	0.048	p<0.001
CB (μmol/L)	−0.071 (−0.167 to 0.025)	0.049	0.149
UCB (μmol/L)	−1.092 (−1.186 to −0.998)	0.048	0.061
TC (mmol/L)	1.361 (1.338 to 1.383)	0.011	p<0.001
TG (mmol/L)	0.263 (0.260 to 0.266)	0.015	0.306
iNOS (pg/ml)	−0.505 (−0.597 to −0.414)	0.047	p<0.001
Birth weight (g)	−0.006 (−0.007 to −0.006)	0.001	0.130
Placnetal weight (g)	0.003 (0.003 to 0.004)	0.001	0.392

1 min	−0.879 (−0.925 to−0.832)	0.024	p<0.001
5 min	−0.315 (−0.389 to −0.241)	0.038	p<0.001
BMI – body mass index; GA – gestational age; TBA – total bile acid; CG – cholyglycine; ALT – alanine transaminase; AST – aspartate transaminase; TB – total bilirubin; TG – triglyceride; TC – total cholesterol; CB – conjugated bilirubin; UCB – unconjugated bilirubin.

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