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11 June 2021: Animal Study

Protective Effects of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Combined with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Death via Reducing the Ferroptosis of Hepatocytes

Dong Sun 1BCDEF* , Liu Yang 1BCEF* , Weiping Zheng 23CE , Huan Cao 14BD , Longlong Wu 5DF , Hongli Song 26AG*

DOI: 10.12659/MSM.930258

Med Sci Monit 2021; 27:e930258

Table 1 DCD donor livers ameliorated by NMP combined with BMMSCs.

ParametersNormal groupSCS groupP groupBP group
ValueP value (vs SCS group)ValueP value (vs SCS group)P value (vs P group)
ALT (U/l)31.74±2.00n.a.97.40±2.91n.a.72.84±2.00n.a.0.003#
AST (U/l)49.24±2.77n.a.124.62±3.94n.a97.30±4.26n.a.0.001#
Lactic acid (mmol/l)2.04±0.05n.a.2.48±0.04n.a.2.34±0.11n.a.0.107
Cumulative bile (ml)n.a.n.a.2.92±0.04n.a.3.27±0.06n.a.0.001#
Suzuki score0.40±0.557.60±0.553.40±0.55* 1.60±0.55* 0.016#
n.a. – applicable.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750