22 July 2021 : Database Analysis
Identification of Key Genes and Underlying Mechanisms in Acute Kawasaki Disease Based on Bioinformatics Analysis
Side Gao1BCDEF, Wenjian Ma1BCD, Xuze Lin1BCD, Sizhuang Huang1BC, Mengyue Yu1AG*DOI: 10.12659/MSM.930547
Med Sci Monit 2021; 27:e930547
Table 2 The hub genes in Kawasaki disease.
| Hub genes | Full name | Degrees in PPI | Functions |
|---|---|---|---|
| ITGAX | Integrin alpha-X | 34 | A receptor for fibrinogen. Mediates cell-cell interaction during inflammatory responses |
| SPI1 | Spi-1 proto-oncogene | 29 | A transcriptional activator specifically involved in the differentiation or activation of macrophages or B cells |
| LILRB2 | Leukocyte immunoglobulin-like receptor subfamily B member 2 | 27 | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA. Involved in immune response and the development of tolerance |
| MMP9 | Matrix metalloproteinase-9 | 24 | Mediates local proteolysis of extracellular matrix. Plays a role in leukocyte migration, chemotaxis, and inflammation and contributes to unstable atherosclerotic plaques |
| S100A12 | S100 calcium-binding protein A12 | 22 | A calcium-, zinc-, and copper-binding protein that regulates inflammatory processes and immune response. |
| C3AR1 | Complement component 3a receptor 1 | 20 | Receptor for anaphylatoxin C3a. Mediates chemotaxis, granule enzyme release and superoxide anion production |
| RETN | Resistin | 20 | A kind of adipokine that links obesity to diabetes and promotes chemotaxis, inflammation, and atherosclerosis |
| MAPK14 | Mitogen-activated protein kinase 14 | 19 | One of the 4 p38 MAPKs. Plays a key role in cellular responses evoked by proinflammatory cytokines and leads to direct activation of transcription factors |
| TLR5 | Toll-like receptor 5 | 18 | Pattern recognition receptor on cell surface. Participates in activation of innate immunity and inflammation |
| MYD88 | Myeloid differentiation primary response protein | 17 | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in innate immune response |