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22 July 2021: Database Analysis

Identification of Key Genes and Underlying Mechanisms in Acute Kawasaki Disease Based on Bioinformatics Analysis

Side Gao BCDEF , Wenjian Ma BCD , Xuze Lin BCD , Sizhuang Huang BC , Mengyue Yu AG*

DOI: 10.12659/MSM.930547

Med Sci Monit 2021; 27:e930547

Table 2 The hub genes in Kawasaki disease.

Hub genesFull nameDegrees in PPIFunctions
ITGAXIntegrin alpha-X34A receptor for fibrinogen. Mediates cell-cell interaction during inflammatory responses
SPI1Spi-1 proto-oncogene29A transcriptional activator specifically involved in the differentiation or activation of macrophages or B cells
LILRB2Leukocyte immunoglobulin-like receptor subfamily B member 227Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA. Involved in immune response and the development of tolerance
MMP9Matrix metalloproteinase-924Mediates local proteolysis of extracellular matrix. Plays a role in leukocyte migration, chemotaxis, and inflammation and contributes to unstable atherosclerotic plaques
S100A12S100 calcium-binding protein A1222A calcium-, zinc-, and copper-binding protein that regulates inflammatory processes and immune response.
C3AR1Complement component 3a receptor 120Receptor for anaphylatoxin C3a. Mediates chemotaxis, granule enzyme release and superoxide anion production
RETNResistin20A kind of adipokine that links obesity to diabetes and promotes chemotaxis, inflammation, and atherosclerosis
MAPK14Mitogen-activated protein kinase 1419One of the 4 p38 MAPKs. Plays a key role in cellular responses evoked by proinflammatory cytokines and leads to direct activation of transcription factors
TLR5Toll-like receptor 518Pattern recognition receptor on cell surface. Participates in activation of innate immunity and inflammation
MYD88Myeloid differentiation primary response protein17Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in innate immune response

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750