15 October 2021>: Clinical Research
The Serum Metabolomics Study of Liver Failure and Artificial Liver Therapy Intervention
Shipeng Huang 1ABC , Dali Hu 2BCD , Songsong Yuan 2BCD , Ying He 2BCD , Chengmu Li 2BCD , Ying Zhu 2BCD , Xiaoping Wu 2AEF*DOI: 10.12659/MSM.930638
Med Sci Monit 2021; 27:e930638
Table 3 Qualitative and quantitative analysis of 35 chromatographic peaks in serum from the liver failure group and chronic hepatitis groups and from the healthy control group.
Number | Retention time | Endogenousmetabolites | Healthy control group (Peak area ratio) | Liver failure group (Peak area ratio) | Chronic hepatitis group (Peak area ratio) | Liver failure artificial liver group (Peak area ratio) |
---|---|---|---|---|---|---|
1 | 6.516 | Boric acid | 0.0557±0.0206 | 0.0285±0.0163 | 0.0593±0.0209 | 0.0541±0.0054 |
2 | 8.546 | N,N-diethyl acetamide | 0.0244±0.0123 | 0.0339±0.0453 | 0.0166±0.0081 | 0.0207±0.0123 |
3 | 8.634 | 2-(methoxyimino)-propanoic acid | 0.0941±0.2183 | 0.0846±0.2250 | 0.1955±0.1567 | 0.1248±0.0241 |
4 | 8.957 | Lactic acid | 1.6453±0.6144 | 3.3355±2.7454 | 1.8004±0.9988 | 1.7151±0.1205 |
5 | 10.587 | L-alanine | 0.0853±0.0204 | 0.1168±0.1166 | 0.0856±0.0350 | 0.0927±0.0354 |
6 | 11.269 | Glycine | 0.1211±0.1289 | 0.0760±0.0602 | 0.2922±0.1592 | 0.2289±0.0843 |
7 | 11.640 | 2-hydroxybutyric acid | 0.0588±0.0204 | 0.1011±0.0831 | 0.0628±0.0196 | 0.0607±0.0401 |
8 | 12.934 | (R)-3-hydroxybutyric acid | 0.1029±0.0795 | 0.1339±0.1301 | 0.0873±0.0456 | 0.0948±0.0379 |
9 | 15.086 | L-valine | 0.1018±0.0297 | 0.0938±0.0520 | 0.1213±0.0521 | 0.1124±0.0218 |
10 | 15.980 | Urea | 1.7944±1.1465 | 1.6663±1.2914 | 1.2255±0.4506 | 1.4851±0.0985 |
11 | 17.210 | L-leucine | 0.0176±0.0083 | 0.0267±0.0269 | 0.0314±0.0248 | 0.0283±0.0377 |
12 | 17.457 | Phosphate | 0.4465±0.1169 | 0.4517±0.2117 | 0.3889±0.1438 | 0.4238±0.0864 |
13 | 17.527 | Glycerol | 0.2428±0.0929 | 0.3195±0.1193 | 0.1805±0.0435 | 0.2249±0.0347 |
14 | 17.904 | L-Proline | 0.0880±0.0189 | 0.1630±0.1296 | 0.0985±0.0402 | 0.0919±0.0134 |
15 | 18.310 | Glycine | 0.0039±0.0103 | 0.0062±0.0219 | 0.0097±0.0071 | 0.0084±0.0146 |
16 | 20.374 | Serine | 0.0148±0.0090 | 0.0282±0.0240 | 0.0227±0.0165 | 0.0216±0.0513 |
17 | 21.027 | L-threonine | 0.0231±0.0106 | 0.0600±0.0640 | 0.0330±0.0177 | 0.0289±0.0094 |
18 | 21.204 | L-methionine | 0.0069±0.0063 | 0.0586±0.0656 | 0.0062±0.0064 | 0.0068±0.0106 |
19 | 22.586 | Aminomalonic acid | 0.0678±0.1347 | 0.0347±0.0172 | 0.1173±0.0896 | 0.0894±0.0664 |
20 | 23.286 | L-5-oxoproline | 0.2219±0.0641 | 0.4132±0.5095 | 0.1829±0.0558 | 0.2067±0.0431 |
21 | 23.562 | DL-phenylalanine | 0.0547±0.0156 | 0.1044±0.0459 | 0.0546±0.0143 | 0.0553±0.0582 |
22 | 23.798 | Creatinine | 0.0334±0.0181 | 0.0383±0.0373 | 0.0259±0.0102 | 0.0298±0.1006 |
23 | 24.056 | 2,3,4-trihydroxybutyric acid | 0.0166±0.0090 | 0.0338±0.0324 | 0.0152±0.0098 | 0.0115±0.0194 |
24 | 25.927 | D-(+)-arabitol | 0.0353±0.0246 | 0.0253±0.0131 | 0.0258±0.0119 | 0.0305±0.0409 |
25 | 27.150 | 1,5-anhydrohexitol | 0.2217±0.1018 | 0.2539±0.1820 | 0.2762±0.0997 | 0.2821±0.0348 |
26 | 27.756 | d-mannose | 7.4102±1.1994 | 7.0861±3.0331 | 5.4392±1.3233 | 6.4089±0.8594 |
27 | 27.956 | D-(+)-talose | 1.5854±0.4940 | 1.9203±1.5121 | 0.9606±0.3202 | 1.4429±0.1340 |
28 | 29.056 | Palmitic acid | 0.5809±0.1340 | 0.8496±0.2942 | 0.5304±0.1348 | 0.5675±0.0645 |
29 | 30.103 | Myo-inositol | 0.0614±0.0409 | 0.0816±0.0636 | 0.0328±0.0123 | 0.0459±0.0458 |
30 | 31.368 | (Z,Z)-9,12-octadecadienoic acid | 0.1156±0.0709 | 0.2173±0.1345 | 0.1092±0.0449 | 0.9856±0.0345 |
31 | 31.438 | (E)-13-octadecenoic acid | 0.2177±0.1320 | 0.4594±0.2823 | 0.2013±0.0934 | 0.2264±0.0387 |
32 | 31.844 | Stearic acid | 0.2371±0.0551 | 0.3420±0.1183 | 0.2459±0.0678 | 0.2508±0.1005 |
33 | 38.220 | 1-Monopalmitin | 0.2405±0.0596 | 0.2112±0.0790 | 0.1954±0.0313 | 0.2186±0.0954 |
34 | 41.255 | Glycerol monostearate | 0.3886±0.1095 | 0.3802±0.1050 | 0.1362±0.0239 | 0.2633±0.0097 |
35 | 46.431 | Cholesterol | 1.1187±0.3268 | 2.0769±0.7983 | 0.7551±0.1954 | 0.9842±0.0895 |