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12 October 2021: Review Articles

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Lizhe Guo 12E , Zhaosheng Jin 3F , Tong J. Gan 3E , E Wang 12A*

DOI: 10.12659/MSM.930776

Med Sci Monit 2021; 27:e930776

Table 1 The arterial blood gas of a 37-year-old male patient diagnosed with COVID-19 was found to have undergone ECMO due to silent hypoxemia despite being mechanically ventilated. Blood gas analysis showed that FCOHb was increased, and SaO2 was significantly lower than SpO2.

Pre-ECMOOn-ECMONormal range
SpO (%)95%95%95~100
pCO (mmHg)40.440.135~45
pO (mmHg)43.246.080~100
Hb (g/dl)8.68.712.0~17.5
SaO (%)83.686.593~98
FCOHb (%)7.18.30~1.5
FMetHb (%)1.41.32~7
Base excess (mmol/L)−0.3−6.4−3~3
Lactate (mmol/L)
Glucose (mmol/L)
K (mmol/L)
COVID-19 – coronavirus disease-2019; ECMO – extracorporeal membrane oxygenation; SpO – pulse oximetric oxygen saturation; SaO – arterial oxygen saturation; FCOHb – fraction of carboxyhaemoglobin; pCO – partial pressure of carbon dioxide; pO – partial pressure of oxygen; Hb – hemoglobin; FMetHb – fraction of methemoglobin.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750