Association Between Body Mass Index and Thyroid Function in Euthyroid Chinese Adults

Jing Fu; Lin Zhang; Yu An; Yan Duan; Jia Liu; Guang Wang

doi:10.12659/MSM.930865

19 March 2021 : Clinical Research

Association Between Body Mass Index and Thyroid Function in Euthyroid Chinese Adults

Jing Fu^1ACE, Lin Zhang^1BDF, Yu An^1C, Yan Duan^1B, Jia Liu^1ADE*, Guang Wang^12AF

DOI: 10.12659/MSM.930865

Med Sci Monit 2021; 27:e930865

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Table 2 Associations between thyroid function and laboratory indices.

	TSH				FT3
	r	P value	β	P value	r	P value	β	P value
BMI	0.052^*	0.041	0.040	0.115	0.138^**	<0.001	0.120^**	<0.001
TC	0.020	0.448	0.004	0.869	−0.060^*	0.021	−0.035	0.140
LDL-C	0.005	0.838	<0.001	0.998	0.027	0.302	0.030	0.212
HDL-C	−0.015	0.551	−0.021	0.459	−0.187^**	<0.001	−0.029	0.274
TG	0.078^**	0.003	0.015	0.564	0.015	0.561	−0.055^*	0.023
FBG	−0.018	0.476	−0.021	0.424	0.039	0.133	0.018	0.464
FINS	0.078^**	0.002	0.080^**	0.006	0.148^**	<0.001	0.097^**	<0.001
HOMA-IR	0.063^*	0.014	0.059^*	0.045	0.140^**	<0.001	0.084^**	0.002
HOMA-β	0.075^**	0.004	0.091^**	0.001	0.107^**	<0.001	0.060^*	0.021
WBC	−0.012	0.628	−0.015	0.576	0.088^**	0.001	0.013	0.581
Neutrophils	−0.010	0.707	−0.023	0.370	0.042	0.105	−0.007	0.775
Lymphocyte	−0.012	0.637	0.006	0.816	0.108^**	0.000	0.039	0.105
Platelet	0.009	0.721	−0.027	0.310	−0.021	0.412	0.023	0.352
NLR	−0.009	0.717	−0.024	0.351	−0.044	0.085	−0.030	0.200


BMI	−0.016	0.518	−0.027	0.282	0.133^**	<0.001	0.129^**	<0.001
TC	0.019	0.453	0.049	0.053	−0.055^*	0.033	−0.066^*	0.010
LDL-C	0.030	0.241	0.047	0.062	0.003	0.912	−0.013	0.620
HDL-C	−0.027	0.298	0.046	0.105	−0.126^**	<0.001	−0.070^*	0.015
TG	0.032	0.210	0.018	0.480	−0.013	0.613	−0.057^*	0.031
FBG	0.048	0.060	0.067^*	0.010	−0.012	0.635	−0.049	0.063
FINS	−0.038	0.134	−0.052	0.070	0.164^**	<0.001	0.135^**	<0.001
HOMA-IR	−0.033	0.205	−0.046	0.107	0.153^**	<0.001	0.120^**	<0.001
HOMA-β	−0.043	0.093	−0.060^*	0.028	0.134^**	<0.001	0.111^**	<0.001
WBC	0.084^**	0.001	0.060^*	0.021	−0.019	0.458	−0.056^*	0.031
Neutrophils	0.069^*	0.007	0.056^*	0.028	−0.041	0.110	−0.068^**	0.008
Lymphocyte	0.063^*	0.014	0.037	0.151	0.021	0.415	−0.009	0.726
Platelet	0.033	0.200	0.054^*	0.038	−0.045	0.083	−1.127	0.260
NLR	0.014	0.598	0.024	0.346	−0.053^*	0.042	−0.052^*	0.043
Values of r represent correlation coefficient. Values of β are standardized regression coefficients. BMI – body mass index; TSH – thyroid stimulating hormone; FT3 – free triiodothyronine; FT4 – free thyroxine; TC – total cholesterol; LDL-C – low-density lipoprotein cholesterol; HDL-C – high-density lipoprotein cholesterol; TG – triglycerides; FBG – fasting blood glucose; FINS – fasting serum insulin; HOMA-IR – homeostasis model assessment of insulin resistance; HOMA-β – homeostasis model assessment of β cell function; WBC – white blood cell; NLR – neutrophil to lymphocyte ratio. BMI was estimated after adjustment for gender and age; other variables were estimated after adjustment for gender, age and BMI. ^* ^**

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Association Between Body Mass Index and Thyroid Function in Euthyroid Chinese Adults

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