Relationship of Programmed Death-1 (PD-1) and Programmed Death Ligand-1 (PD-L1) Polymorphisms with Overall Cancer Susceptibility: An Updated Meta-Analysis of 28 Studies with 60 612 Subjects

Wenjing Zhang; Yuxuan Song; Xiangcheng Zhang

doi:10.12659/MSM.932146

24 May 2021: Meta-Analysis

Relationship of Programmed Death-1 (PD-1) and Programmed Death Ligand-1 (PD-L1) Polymorphisms with Overall Cancer Susceptibility: An Updated Meta-Analysis of 28 Studies with 60 612 Subjects

Wenjing Zhang ^12BCDEF , Yuxuan Song ^34ABEF* , Xiangcheng Zhang ^1ACEG*

DOI: 10.12659/MSM.932146

Med Sci Monit 2021; 27:e932146

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Background Material and Methods Results Discussion Conclusions References

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Table 1 Characteristics of the selected articles.

Genotype	n	First author	Year	Country	Ethnicity	Cancer type	Case			Control			HWE	Genotype methods

PD-1 rs10204525	6	Zhou R-M	2016	China	Asian	Esophageal cancer	33	226	325	51	238	296	0.748	PCR–LDR
		Zang B	2019	China	Asian	Esophageal cancer	63	329	420	50	359	551	0.388	qRT-PCR
		Ren H-T	2016	China	Asian	Breast cancer	54	248	257	51	240	291	0.879	PCR
		Tang WF	2015	China	Asian	Gastric cancer	21	123	169	53	219	309	0.119	PCR–LDR
		Qiu H	2014	China	Asian	Esophageal cancer	43	240	317	63	243	345	0.038	PCR–LDR
		Tang WF	2017	China	Asian	Esophageal cancer	544	397	98	870	672	132	0.887	PCR–LDR

PD-1 rs11568821	5	Fathi F	2019	Iran	Asian	Basal cell cancer	3	183	24	7	58	255	0.099	PCR-RFLP
		Bayram S	2012	Turkey	Asian	Hepatocellular cancer	0	191	45	0	56	180	0.038	PCR-RFLP
		Haghshenas MR	2011	Iran	Asian	Breast cancer	8	365	63	4	55	231	0.725	PCR-RFLP
		Ma Y	2015	China	Asian	Non-small cell lung cancer	0	426	102	2	142	456	0.009	PCR-RFLP
		Fathi F	2018	Iran	Asian	Carcinomas of head and neck	4	119	27	5	32	113	0.162	PCR-RFLP

PD-L1 rs17718883	3	Xie Q	2018	China	Asian	Hepatocellular carcinoma	215	8	2	108	69	23	0.025	PCR-RFLP
		Li Q	2016	China	Asian	Gastric cancer	87	13	1	77	48	16	0.054	PCR
		Chen S	2017	China	Asian	Hepatocellular carcinoma	122	1	0	77	48	16	0.054	PCR

PD-1 rs2227981	11	Fathi F	2019	Iran	Asian	Basal cell carcinoma	30	87	93	150	134	36	0.466	PCR-RFLP
		Zhou R-M	2016	China	Asian	Esophageal cancer	52	241	291	46	229	310	0.683	PCR–LDR
		Li XF	2016	China	Asian	Cervical cancer	44	167	45	87	101	62	0.004	PCR-RFLP
		Ma Y	2015	China	Asian	Non-small cell lung cancer	68	216	244	98	246	256	0.004	PCR-RFLP
		Fathi F	2018	Iran	Asian	Carcinomas of head and neck	16	69	65	13	71	66	0.317	PCR-RFLP
		Hua Z	2011	China	Asian	Breast cancer	22	169	295	24	210	244	0.012	PCR-RFLP
		Mojtahedi Z	2012	Iran	Asian	Colorectal cancer	32	109	59	36	89	75	0.290	PCR-RFLP
		Li Y	2016	China	Asian	Ovarian cancer	351	233	351	51	250	319	0.837	PCR–LDR
		We L	2017	China	Asian	Ovarian cancer	7	42	67	6	44	60	0.571	RT-PCR
		Haghshenas MR	2010	Iran	Asian	Breast cancer	50	191	194	46	145	137	0.445	PCR-RFLP
		Sanaz Savabkar	2013	Iran	Asian	Gastric cancer	6	66	50	7	70	89	0.136	PCR-RFLP

PD-1 rs2227982	10	Zhou R-M	2016	China	Asian	esophageal cancer	149	305	130	150	297	138	0.702	PCR-LDR
		Tan D	2017	China	Asian	ovarian cancer	87	60	17	111	48	11	0.075	qRT-PCR
		Ma Y	2015	China	Asian	non-small cell lung cancer	343	148	37	404	168	28	0.056	PCR-RFLP
		Hua Z	2011	China	Asian	breast cancer	111	249	127	95	268	143	0.121	PCR-RFLP
		Kasamatsu T	2019	Japan	Asian	multiple myeloma	55	116	40	43	55	26	0.285	PCR-RFLP
		Tang WF	2015	China	Asian	gastric cancer	75	168	87	163	292	148	0.448	PCR-LDR
		Qiu H	2014	China	Asian	esophageal cancer	159	303	154	189	325	167	0.245	PCR-LDR
		Tang WF	2017	China	Asian	esophageal cancer	220	549	272	416	816	442	0.309	PCR-LDR
		Tang WF	2017	China	Asian	esophageal cancer	87	168	75	148	292	163	0.448	PCR-LDR
		Ren H-T	2016	China	Asian	breast Cancer	172	257	128	137	299	146	0.503	PCR

PD-L1 rs2890658	6	Chen Y-B	2014	China	Asian	non-small cell lung cancer	242	48	3	266	26	1	0.671	PCR-RFLP
		Xie Q	2018	China	Asian	hepatocellular carcinoma	170	49	6	139	55	6	0.844	PCR-RFLP
		Zhou R-M	2017	china	Asian	esophageal cancer	18	161	396	15	144	418	0.541	PCR-LDR
		Li Q	2016	china	Asian	gastric cancer	79	20	2	98	39	4	0.959	PCR
		Ma Y	2015	China	Asian	non-small cell lung cancer	416	106	6	512	84	4	0.785	PCR-RFLP
		Chen S	2017	china	Asian	hepatocellular carcinoma	95	27	1	98	39	4	0.959	PCR

PD-1 rs36084323	10	Zhou R-M	2016	China	Asian	esophageal cancer	134	303	147	142	298	145	0.649	PCR-LDR
		Zang B	2019	China	Asian	esophageal cancer	8	132	673	12	188	761	0.919	qRT-PCR
		Hua Z	2011	China	Asian	breast cancer	116	271	103	112	260	140	0.673	PCR
		Kasamatsu T	2019	Japan	Asian	multiple myeloma	50	110	51	33	54	37	0.154	PCR-RFLP
		Bôas Gomez GV	2018	Brazil	Caucasian	Cutaneous Melanoma	6	18	226	0	25	225	0.405	qRT-PCR
		Ma Y	2015	China	Asian	non-small cell lung cancer	138	246	144	148	296	156	0.747	PCR-RFLP
		Li Y	2016	China	Asian	ovarian cancer	169	301	150	129	323	168	0.251	PCR-LDR
		We L	2017	china	Asian	ovarian cancer	37	57	22	21	53	36	0.849	PCR-LDR
		Zhao Y	2018	China	Asian	colorectal cancer	116	207	96	123	253	121	0.686	PCR-RFLP
		Tang WF	2017	China	Asian	esophageal cancer	282	521	238	444	800	430		PCR-LDR

PD-L1 rs4143815	6	Wang W	2013	China	Asian	Gastric cancer	45	72	88	135	188	70	0.746	PCR
		Tan D	2017	China	Asian	Ovarian cancer	31	82	51	54	78	38	0.334	qRT-PCR
		Xie Q	2018	China	Asian	Hepatocellular carcinoma	50	101	74	65	104	31	0.316	PCR-RFLP
		Zhou R-M	2017	China	Asian	Esophageal cancer	211	277	87	203	289	85	0.275	PCR-LDR
		Li Q	2016	China	Asian	Gastric cancer	41	47	13	49	76	16	0.09	PCR
		Chen S	2017	China	Asian	Hepatocellular carcinoma	50	50	23	49	76	16	0.09	PCR

PD-1 rs7421861	8	Tang WF	2017	China	Asian	Esophageal cancer	7	91	226	22	168	408	0.368	PCR-LDR
		Zang B	2019	China	Asian	Esophageal cancer	343	370	100	457	411	92	0.977	PCR-RFLP
		Hua Z	2011	China	Asian	Breast cancer	11	146	333	12	130	370	0.884	PCR-RFLP
		Tang WF	2015	China	Asian	Gastric cancer	7	91	226	22	168	408	0.367	PCR-LDR
		Qiu H	2014	China	Asian	Esophageal cancer	21	168	411	25	188	460	0.295	PCR-LDR
		Jie Ge	2015	China	Asian	Colorectal cancer	14	187	395	17	163	440	0.684	PCR-RFLP
		Tang WF	2017	China	Asian	Esophageal cancer	41	358	642	54	454	1166	0.232	PCR-LDR
		Ren H-T	2016	China	Asian	Breast cancer	23	196	341	28	205	347	0.746	PCR

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Relationship of Programmed Death-1 (PD-1) and Programmed Death Ligand-1 (PD-L1) Polymorphisms with Overall Cancer Susceptibility: An Updated Meta-Analysis of 28 Studies with 60 612 Subjects

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