24 May 2021 : Meta-Analysis
Relationship of Programmed Death-1 (PD-1) and Programmed Death Ligand-1 (PD-L1) Polymorphisms with Overall Cancer Susceptibility: An Updated Meta-Analysis of 28 Studies with 60 612 Subjects
Wenjing Zhang12BCDEF, Yuxuan Song34ABEF, Xiangcheng Zhang1ACEG*DOI: 10.12659/MSM.932146
Med Sci Monit 2021; 27:e932146
Table 3 Meta-analyses on PD-1 and PD-L1 variants and cancer susceptibility.
| Genotype | Contrast model | OR (95%I) | P | Test for heterogeneity | Analysis model | |
|---|---|---|---|---|---|---|
| I2 (%) | P | |||||
| rs10204525 | A vs G | 1.002 (0.889–1.129) | 0.976 | 67.50 | 0.009 | R |
| GA vs GG | 1.073 (0.866–1.331) | 0.517 | 49.00 | 0.081 | R | |
| AA vs GG | 1.097 (0.817–1.474) | 0.539 | 68.30 | 0.008 | R | |
| AA+GA vs GG | 1.068 (0.843–1.354) | 0.586 | 61.80 | 0.023 | R | |
| AA vs AG+GG | 0.995 (0.856–1.599) | 0.943 | 59.40 | 0.031 | R | |
| rs11568821 | G vs A | 1.314 (1.116–1.547) | 0.001 | 0.00 | 0.869 | F |
| AG vs AA | 0.911 (0.437–1.898) | 0.803 | 0.00 | 0.716 | F | |
| GG vs AA | 1.298 (0.644–2.618) | 0.466 | 0.00 | 0.691 | F | |
| GG+GA vs AA | 1.221 (0.606–2.459) | 0.576 | 0.00 | 0.698 | F | |
| GG vs GA+AA | 1.061 (0.955–1.180) | 0.270 | 0.00 | 1.000 | F | |
| rs17718883 | C vs G | 14.156 (4.024–49.805) | 85.10 | 0.001 | R | |
| GC vs GG | 2.077 (0.645–6.691) | 0.221 | 0.00 | 0.626 | F | |
| CC vs GG | 25.488 (8.494–76.481) | 0.00 | 0.829 | F | ||
| CC+CG vs GG | 16.615 (5.565–49.609) | 0.00 | 0.855 | F | ||
| CC vs CG+GG | 16.361 (4.203–63.685) | 84.60 | 0.001 | R | ||
| rs2227981 | C vs T | 1.077 (0.753–1.539) | 0.686 | 96.20 | R | |
| TC vs TT | 1.056 (0.542–2.058) | 0.873 | 94.60 | R | ||
| CC vs TT | 1.095 (0.531–2.260) | 0.805 | 95.20 | R | ||
| CC+CT vs TT | 1.085 (0.548–2.146) | 0.815 | 95.50 | R | ||
| CC vs CT+TT | 1.050 (0.754–1.464) | 0.771 | 91.60 | R | ||
| rs2227982 | C vs T | 0.981 (0.898–1.071) | 0.665 | 56.00 | 0.015 | R |
| TC vs TT | 1.050 (0.952–1.158) | 0.330 | 0.00 | 0.773 | F | |
| CC vs TT | 0.977 (0.824–1.157) | 0.787 | 50.20 | 0.034 | R | |
| CC+CT vs TT) | 1.028 (0.938–1.127) | 0.555 | 0.00 | 0.498 | F | |
| CC vs CT+TT | 0.942 (0.809–1.096) | 0.437 | 64.30 | 0.003 | R | |
| rs2890658 | A vs C | 1.002 (0.718–1.400) | 0.989 | 79.80 | R | |
| CA vs CC | 1.154 (0.902–1.476) | 0.254 | 0.00 | 0.933 | F | |
| AA vs CC | 1.121 (0.696–1.806) | 0.638 | 0.00 | 0.542 | F | |
| AA+AC vs CC | 1.159 (0.915–1.469) | 0.220 | 0.00 | 0.640 | F | |
| AA vs AC+CC | 1.002 (0.662–1.515) | 0.994 | 76.90 | 0.001 | R | |
| rs36084323 | G vs A | 0.930 (0.851–1.016) | 0.106 | 49.80 | 0.036 | R |
| AG vs AA | 0.933 (0.842–1.034) | 0.189 | 31.30 | 0.158 | F | |
| GG vs AA | 0.829 (0.701–0.981) | 0.029 | 38.80 | 0.099 | R | |
| GG+GA vs AA | 0.903 (0.819–0.995) | 0.038 | 35.10 | 0.127 | F | |
| GG vs GA+AA | 0.913 (0.798–1.044) | 0.183 | 49.00 | 0.039 | R | |
| rs4143815 | C vs G | 0.752 (0.555–1.019) | 0.066 | 86.90 | R | |
| GC vs GG | 0.560 (0.365–0.860) | 0.008 | 76.00 | 0.001 | R | |
| CC vs GG | 0.537 (0.315–0.918) | 0.023 | 82.00 | R | ||
| CC+CG vs GG | 0.555 (0.351–0.877) | 0.012 | 81.50 | R | ||
| CC vs CG+GG | 0.809 (0.575–1.138) | 0.223 | 75.70 | 0.001 | R | |
| rs7421861 | T vsC | 0.980 (0.855–1.124) | 0.777 | 74.20 | R | |
| TC vsCC | 1.202 (1.031–1.402) | 0.019 | 0.00 | 0.963 | F | |
| TT vs CC | 1.171 (0.969–1.416) | 0.102 | 19.80 | 0.272 | F | |
| TT+CT vs CC | 1.181 (1.020–1.368) | 0.026 | 0.00 | 0.642 | F | |
| TT vs CT+CC | 0.947 (0.811–1.106) | 0.492 | 68.10 | 0.003 | R | |