A Retrospective Study of 268 Patients with SARS-CoV-2 Infection to Evaluate the Association Between Blood Glucose and Severity of COVID-19 Pneumonia and Patient Mortality

07 August 2021 : Clinical Research

Yaoyao Sun^12CDE, Nan Jiang^1ABD, Zhijun Li

^2CD, Xinwei Li^2DF, Bo Yang^3B, Daoyuan Si^4D, Piyong Ma^5BF, Jinnan Zhang^6BF, Ningning Jia^2EF, Mengdi Jin^2E, Yang He

^2C, Xingyao Cui^2D, Tianji Liu^1AB, Qiong Yu^2ABCDF*

DOI: 10.12659/MSM.932156

Med Sci Monit 2021; 27:e932156

Background Material and Methods Results Discussion Conclusions References

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Table 1 The baseline characteristics of patients with COVID-19 (n, interquartile range, or percentage).

Characteristics	Total (n=268)	Severe (n=96)	Non-severe (n=172)	P
Age, years	57.75 (67.00, 73.00)	70.00 (64.00, 76.75)	65.00 (54.00, 72.00)	<0.001
Sex				0.036
Male	139 (51.9)	58 (60.4)	81 (47.1)
Female	129 (48.1)	38 (39.6)	91 (52.9)
Comorbidities
Hypertension	43/109 (39.4)	27/69 (39.1)	16/40 (40.0)	0.929
Diabetes	21/109 (19.3)	17/69 (24.6)	4/40 (10.0)	0.062
Cardiovascular disease	12/109 (11.0)	8/69 (11.6)	4/40 (10.0)	1.000
Chronic kidney disease	1/109 (0.9)	1/69 (1.4)	0/40 (0.0)	1.000
Chronic liver disease	1/109 (0.9)	1/69 (1.4)	0/40 (0.0)	1.000
Chronic obstructive pulmonary disease	3/109 (2.8)	2/69 (2.9)	1/40 (2.5)	1.000
Blood glucose, mmol/L	6.20 (5.28, 8.14)	7.42 (6.02, 10.55)	5.72 (5.12, 6.89)	<0.001
Leukocyte count, ×10/L	6.17 (4.80, 8.99)	9.26 (6.03, 12.35)	5.64 (4.53, 6.98)	<0.001
Neutrophil count, ×10/L	4.37 (3.13, 7.42)	7.94 (4.55, 11.91)	3.81 (2.61, 4.78)	<0.001
Lymphocyte count, ×10/L	0.97 (0.65, 1.42)	0.64 (0.45, 0.89)	1.22 (0.85, 1.60)	<0.001
ALT, U/L	24.50 (16.00, 41.00)	29.00 (19.00, 42.75)	23.00 (14.00, 40.00)	0.021
AST, U/L	27.00 (19.00, 45.00)	41.00 (25.25, 62.00)	23.50 (18.00, 34.00)	<0.001
LDH, U/L	290.00 (225.25, 455.00)	480.00 (333.25, 635.50)	252.50 (209.75, 328.75)	<0.001
Total bilirubin, μmol/L	10.50 (7.30, 14.60)	13.10 (9.53, 18.20)	9.50 (7.00, 13.00)	<0.001
Creatinine, μmol/L	74.50 (60.25, 92.75)	85.50 (68.25, 109.75)	70.00 (59.00, 84.00)	<0.001
Duration of hospitalization, days	20.00 (9.25, 27.00)	16.00 (5.25, 28.00)	21.00 (12.25, 27.00)	0.058
ALT – alanine aminotransferase; AST – aspartate transaminase; LDH – lactic dehydrogenase

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