Identification of m6A-Related Biomarkers Associated with Prognosis of Colorectal Cancer

Zhiyong Zhang; Xin Zhang

doi:10.12659/MSM.932370

10 August 2021: Database Analysis

Identification of m6A-Related Biomarkers Associated with Prognosis of Colorectal Cancer

Zhiyong Zhang ^ABCDEF* , Xin Zhang ^EF

DOI: 10.12659/MSM.932370

Med Sci Monit 2021; 27:e932370

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Supplementary Table 1 Detailed information (including univariates Cox regression P value and HR score) of 146 m6A-related genes that were associated with the overall survival of CRC patients.

Ensembl ID	Cox p value	HR	chr	Source	Type	Start	End	Strand	Gene type	Gene name
ENSG00000058404	0	3	chr7	HAVANA	Gene	44217150	44334577	−	Protein coding	CAMK2B
ENSG00000069696	0	1.4	chr11	HAVANA	Gene	637293	640706	+	Protein coding	DRD4
ENSG00000072832	0	1.2	chr4	HAVANA	Gene	5748084	5893058	−	Protein coding	CRMP1
ENSG00000077454	0	1.17	chr7	HAVANA	Gene	1.01E+08	1.01E+08	−	Protein coding	LRCH4
ENSG00000078018	0	1.69	chr2	HAVANA	Gene	2.09E+08	2.1E+08	+	Protein coding	MAP2
ENSG00000130294	0	1.21	chr2	HAVANA	Gene	2.41E+08	2.41E+08	−	Protein coding	KIF1A
ENSG00000133069	0	2.31	chr1	HAVANA	Gene	2.05E+08	2.05E+08	+	Protein coding	TMCC2
ENSG00000142549	0	1.45	chr19	HAVANA	Gene	51311848	51330354	+	Protein coding	IGLON5
ENSG00000160117	0	1.64	chr19	HAVANA	Gene	17281645	17287646	+	Protein coding	ANKLE1
ENSG00000167311	0	1.86	chr11	HAVANA	Gene	3638503	3642316	−	Protein coding	ART5
ENSG00000169169	0	1.65	chr19	HAVANA	Gene	49690898	49713731	+	Protein coding	CPT1C
ENSG00000187730	0	1.27	chr1	HAVANA	Gene	2019298	2030758	+	Protein coding	GABRD
ENSG00000104687	0.001	0.98	chr8	HAVANA	Gene	30678061	30727999	−	Protein coding	GSR
ENSG00000115694	0.001	1.08	chr2	HAVANA	Gene	2.41E+08	2.42E+08	−	Protein coding	STK25
ENSG00000148948	0.001	4.76	chr11	HAVANA	Gene	40114203	41459773	−	Protein coding	LRRC4C
ENSG00000151640	0.001	1.59	chr10	HAVANA	Gene	1.32E+08	1.32E+08	+	Protein coding	DPYSL4
ENSG00000168994	0.001	1.09	chr6	HAVANA	Gene	3722614	3752026	−	Protein coding	PXDC1
ENSG00000250510	0.001	1.97	chr12	HAVANA	Gene	6821545	6829972	+	Protein coding	GPR162
ENSG00000076344	0.002	1.23	chr16	HAVANA	Gene	268301	275980	−	Protein coding	RGS11
ENSG00000109606	0.002	0.95	chr4	HAVANA	Gene	24517441	24584550	−	Protein coding	DHX15
ENSG00000112852	0.002	1.4	chr5	HAVANA	Gene	1.41E+08	1.41E+08	+	Protein coding	PCDHB2
ENSG00000130227	0.002	0.93	chr8	HAVANA	Gene	21919671	22006585	+	Protein coding	XPO7
ENSG00000143184	0.002	1.34	chr1	HAVANA	Gene	1.69E+08	1.69E+08	+	Protein coding	XCL1
ENSG00000143303	0.002	1.08	chr1	HAVANA	Gene	1.57E+08	1.57E+08	+	Protein coding	RRNAD1
ENSG00000156006	0.002	0.9	chr8	HAVANA	Gene	18391245	18401218	+	Protein coding	NAT2
ENSG00000172340	0.002	0.98	chr3	HAVANA	Gene	67360460	67654614	−	Protein coding	SUCLG2
ENSG00000178209	0.002	1.01	chr8	HAVANA	Gene	1.44E+08	1.44E+08	−	Protein coding	PLEC
ENSG00000103168	0.003	1.09	chr16	HAVANA	Gene	84177847	84187070	−	Protein coding	TAF1C
ENSG00000121940	0.003	0.8	chr1	HAVANA	Gene	1.09E+08	1.09E+08	−	Protein coding	CLCC1
ENSG00000204947	0.003	2.03	chr7	HAVANA	Gene	1.49E+08	1.49E+08	−	Protein coding	ZNF425
ENSG00000047188	0.004	0.78	chr5	HAVANA	Gene	1.14E+08	1.14E+08	+	Protein coding	YTHDC2
ENSG00000112333	0.004	100.3	chr6	HAVANA	Gene	1.08E+08	1.08E+08	+	Protein coding	NR2E1
ENSG00000149289	0.004	0.71	chr11	HAVANA	Gene	1.1E+08	1.1E+08	+	Protein coding	ZC3H12C
ENSG00000151611	0.004	0.61	chr4	HAVANA	Gene	1.46E+08	1.46E+08	+	Protein coding	MMAA
ENSG00000164307	0.004	0.95	chr5	HAVANA	Gene	96760810	96808100	−	Protein coding	ERAP1
ENSG00000254585	0.004	3.44	chr15	HAVANA	Gene	23643544	23647841	−	Protein coding	MAGEL2
ENSG00000257923	0.004	1.06	chr7	HAVANA	Gene	1.02E+08	1.02E+08	+	Protein coding	CUX1
ENSG00000105737	0.005	1.53	chr19	HAVANA	Gene	41998321	42069498	−	Protein coding	GRIK5
ENSG00000146830	0.005	1.04	chr7	HAVANA	Gene	1.01E+08	1.01E+08	−	Protein coding	GIGYF1
ENSG00000172137	0.005	1.04	chr16	HAVANA	Gene	71358713	71390438	+	Protein coding	CALB2
ENSG00000186591	0.005	1.04	chr7	HAVANA	Gene	1.3E+08	1.3E+08	−	Protein coding	UBE2H
ENSG00000188549	0.005	1.15	chr15	HAVANA	Gene	40331452	40340967	−	Protein coding	C15orf52
ENSG00000197217	0.005	0.91	chr8	HAVANA	Gene	23385783	23457695	−	Protein coding	ENTPD4
ENSG00000104953	0.006	1.73	chr19	HAVANA	Gene	2977446	2995184	+	Protein coding	TLE6
ENSG00000143434	0.006	1.48	chr1	HAVANA	Gene	1.51E+08	1.51E+08	−	Protein coding	SEMA6C
ENSG00000116254	0.007	3.64	chr1	HAVANA	Gene	6101793	6180123	−	Protein coding	CHD5
ENSG00000124074	0.007	1.09	chr16	HAVANA	Gene	67662945	67667265	−	Protein coding	ENKD1
ENSG00000129244	0.007	1.6	chr17	HAVANA	Gene	7646627	7657768	+	Protein coding	ATP1B2
ENSG00000141756	0.007	1.01	chr17	HAVANA	Gene	41812680	41823217	+	Protein coding	FKBP10
ENSG00000168036	0.007	0.99	chr3	HAVANA	Gene	41194741	41260096	+	Protein coding	CTNNB1
ENSG00000233251	0.007	1.79	chr2	HAVANA	Gene	56173534	56185770	−	Antisense	AC007743.1
ENSG00000155975	0.008	0.85	chr8	HAVANA	Gene	17246571	17302427	+	Protein coding	VPS37A
ENSG00000169436	0.008	1.21	chr8	HAVANA	Gene	1.39E+08	1.39E+08	−	Protein coding	COL22A1
ENSG00000173137	0.008	1.04	chr8	HAVANA	Gene	1.44E+08	1.44E+08	+	Protein coding	ADCK5
ENSG00000188559	0.008	0.95	chr20	HAVANA	Gene	20389552	20712488	−	Protein coding	RALGAPA2
ENSG00000205090	0.008	1.83	chr1	HAVANA	Gene	1535174	1540453	−	Protein coding	TMEM240
ENSG00000061273	0.009	1.1	chr12	HAVANA	Gene	47782722	47833132	−	Protein coding	HDAC7
ENSG00000068784	0.009	0.83	chr2	HAVANA	Gene	45388680	45612165	−	Protein coding	SRBD1
ENSG00000128268	0.009	1.08	chr22	HAVANA	Gene	39457344	39492194	+	Protein coding	MGAT3
ENSG00000154359	0.009	0.82	chr8	HAVANA	Gene	12721894	12756073	−	Protein coding	LONRF1
ENSG00000163064	0.009	3.33	chr2	HAVANA	Gene	1.19E+08	1.19E+08	−	Protein coding	EN1
ENSG00000171246	0.009	1.29	chr17	HAVANA	Gene	80467148	80477843	−	Protein coding	NPTX1
ENSG00000213694	0.009	1.15	chr9	HAVANA	Gene	88991447	89005010	+	Protein coding	S1PR3
ENSG00000038210	0.01	0.94	chr4	HAVANA	Gene	25233975	25279092	+	Protein coding	PI4K2B
ENSG00000066557	0.01	0.88	chr1	HAVANA	Gene	70144805	70205620	−	Protein coding	LRRC40
ENSG00000075785	0.01	1.01	chr3	HAVANA	Gene	1.29E+08	1.29E+08	+	Protein coding	RAB7A
ENSG00000115275	0.01	1.03	chr2	HAVANA	Gene	74461057	74465410	−	Protein coding	MOGS
ENSG00000117155	0.01	0.86	chr1	HAVANA	Gene	84643707	84690803	−	Protein coding	SSX2IP
ENSG00000120868	0.01	0.86	chr12	HAVANA	Gene	98645141	98735433	+	Protein coding	APAF1
ENSG00000138604	0.01	0.95	chr15	HAVANA	Gene	69160584	69272217	+	Protein coding	GLCE
ENSG00000175505	0.01	1.08	chr11	HAVANA	Gene	67364168	67374177	−	Protein coding	CLCF1
ENSG00000033100	0.011	1.04	chr7	HAVANA	Gene	1.51E+08	1.51E+08	+	Protein coding	CHPF2
ENSG00000126903	0.011	1.02	chrX	HAVANA	Gene	1.54E+08	1.54E+08	−	Protein coding	SLC10A3
ENSG00000177692	0.011	0.19	chr21	HAVANA	Gene	33485530	33491720	−	Protein coding	DNAJC28
ENSG00000018510	0.012	0.93	chr2	HAVANA	Gene	1.77E+08	1.78E+08	+	Protein coding	AGPS
ENSG00000151623	0.012	0.89	chr4	HAVANA	Gene	1.48E+08	1.48E+08	−	Protein coding	NR3C2
ENSG00000196700	0.012	1.28	chr20	HAVANA	Gene	63956702	63969865	−	Protein coding	ZNF512B
ENSG00000082684	0.013	2.77	chr3	HAVANA	Gene	1.23E+08	1.23E+08	−	Protein coding	SEMA5B
ENSG00000106290	0.013	1.08	chr7	HAVANA	Gene	1E+08	1E+08	−	Protein coding	TAF6
ENSG00000164142	0.013	0.67	chr4	HAVANA	Gene	1.51E+08	1.52E+08	+	Protein coding	FAM160A1
ENSG00000167384	0.013	0.69	chr19	HAVANA	Gene	44474428	44500524	−	Protein coding	ZNF180
ENSG00000109971	0.014	1	chr11	HAVANA	Gene	1.23E+08	1.23E+08	−	Protein coding	HSPA8
ENSG00000148291	0.014	1.02	chr9	HAVANA	Gene	1.33E+08	1.33E+08	+	Protein coding	SURF2
ENSG00000064651	0.015	0.99	chr5	HAVANA	Gene	1.28E+08	1.28E+08	+	Protein coding	SLC12A2
ENSG00000149925	0.015	1	chr16	HAVANA	Gene	30064164	30070457	+	Protein coding	ALDOA
ENSG00000007171	0.016	0.98	chr17	HAVANA	Gene	27756766	27800499	−	Protein coding	NOS2
ENSG00000014164	0.016	1.04	chr8	HAVANA	Gene	1.43E+08	1.44E+08	−	Protein coding	ZC3H3
ENSG00000109320	0.016	0.94	chr4	HAVANA	Gene	1.03E+08	1.03E+08	+	Protein coding	NFKB1
ENSG00000077254	0.018	0.92	chr1	HAVANA	Gene	77695987	77759852	−	Protein coding	USP33
ENSG00000121361	0.018	1.12	chr12	HAVANA	Gene	21764955	21775581	−	Protein coding	KCNJ8
ENSG00000128606	0.018	1.23	chr7	HAVANA	Gene	1.03E+08	1.03E+08	+	Protein coding	LRRC17
ENSG00000160293	0.018	1.03	chr9	HAVANA	Gene	1.34E+08	1.34E+08	−	Protein coding	VAV2
ENSG00000099260	0.019	1.31	chr1	HAVANA	Gene	99645943	99694541	+	Protein coding	PALMD
ENSG00000138131	0.019	1.32	chr10	HAVANA	Gene	98247690	98268250	−	Protein coding	LOXL4
ENSG00000167994	0.02	1.09	chr11	HAVANA	Gene	61897301	61920269	−	Protein coding	RAB3IL1
ENSG00000103966	0.021	0.95	chr15	HAVANA	Gene	41895939	41972578	−	Protein coding	EHD4
ENSG00000160445	0.021	1.06	chr9	HAVANA	Gene	1.29E+08	1.29E+08	−	Protein coding	ZER1
ENSG00000162148	0.022	1.48	chr11	HAVANA	Gene	61481120	61490931	+	Protein coding	PPP1R32
ENSG00000117676	0.023	0.97	chr1	HAVANA	Gene	26529761	26575030	+	Protein coding	RPS6KA1
ENSG00000187244	0.023	1.02	chr19	HAVANA	Gene	44809059	44821421	+	Protein coding	BCAM
ENSG00000109805	0.024	0.91	chr4	HAVANA	Gene	17810902	17844862	+	Protein coding	NCAPG
ENSG00000158106	0.024	1.03	chr8	HAVANA	Gene	1.43E+08	1.43E+08	+	Protein coding	RHPN1
ENSG00000178409	0.024	0.76	chr6	HAVANA	Gene	1.07E+08	1.07E+08	−	Protein coding	BEND3
ENSG00000134057	0.025	0.99	chr5	HAVANA	Gene	69167010	69178245	+	Protein coding	CCNB1
ENSG00000187775	0.025	2.49	chr17	HAVANA	Gene	78423697	78577394	−	Protein coding	DNAH17
ENSG00000204540	0.025	1.2	chr6	HAVANA	Gene	31114750	31140092	+	Protein coding	PSORS1C1
ENSG00000162600	0.026	0.9	chr1	HAVANA	Gene	58415384	58546802	−	Protein coding	OMA1
ENSG00000163132	0.027	1.03	chr4	HAVANA	Gene	4859666	4863936	+	Protein coding	MSX1
ENSG00000137812	0.028	0.85	chr15	HAVANA	Gene	40594020	40664342	+	Protein coding	CASC5
ENSG00000105321	0.029	1.08	chr19	HAVANA	Gene	47255980	47273701	+	Protein coding	CCDC9
ENSG00000130702	0.029	1.02	chr20	HAVANA	Gene	62307955	62367312	−	Protein coding	LAMA5
ENSG00000198026	0.029	1.1	chr20	HAVANA	Gene	45948653	45972172	−	Protein coding	ZNF335
ENSG00000039523	0.031	1.04	chr16	HAVANA	Gene	67518418	67546788	+	Protein coding	FAM65A
ENSG00000090686	0.031	0.89	chr1	HAVANA	Gene	21678298	21783606	−	Protein coding	USP48
ENSG00000189184	0.031	0.88	chr4	HAVANA	Gene	1.38E+08	1.38E+08	−	Protein coding	PCDH18
ENSG00000112367	0.032	0.88	chr6	HAVANA	Gene	1.1E+08	1.1E+08	+	Protein coding	FIG4
ENSG00000143845	0.032	1.22	chr1	HAVANA	Gene	2.04E+08	2.04E+08	−	Protein coding	ETNK2
ENSG00000130158	0.033	1.06	chr19	HAVANA	Gene	11199295	11262481	−	Protein coding	DOCK6
ENSG00000159314	0.033	1.06	chr17	HAVANA	Gene	45393902	45434421	−	Protein coding	ARHGAP27
ENSG00000107829	0.035	1.06	chr10	HAVANA	Gene	1.02E+08	1.02E+08	−	Protein coding	FBXW4
ENSG00000128482	0.035	1.62	chr17	HAVANA	Gene	19411125	19417276	+	Protein coding	RNF112
ENSG00000164181	0.035	0.94	chr5	HAVANA	Gene	60751791	60844389	−	Protein coding	ELOVL7
ENSG00000127838	0.036	1.02	chr2	HAVANA	Gene	2.18E+08	2.18E+08	+	Protein coding	PNKD
ENSG00000180287	0.036	702.2	chr1	HAVANA	Gene	2.42E+08	2.43E+08	−	Protein coding	PLD5
ENSG00000132563	0.037	1.22	chr5	HAVANA	Gene	1.38E+08	1.38E+08	+	Protein coding	REEP2
ENSG00000155760	0.037	1.03	chr2	HAVANA	Gene	2.02E+08	2.02E+08	+	Protein coding	FZD7
ENSG00000183323	0.039	0.83	chr5	HAVANA	Gene	69280175	69332809	−	Protein coding	CCDC125
ENSG00000070031	0.04	1.01	chr11	HAVANA	Gene	626431	627143	−	Protein coding	SCT
ENSG00000115616	0.041	0.94	chr2	HAVANA	Gene	1.03E+08	1.03E+08	+	Protein coding	SLC9A2
ENSG00000134443	0.041	1.07	chr18	HAVANA	Gene	59220168	59230774	+	Protein coding	GRP
ENSG00000143412	0.041	1.06	chr1	HAVANA	Gene	1.51E+08	1.51E+08	+	Protein coding	ANXA9
ENSG00000108395	0.042	0.9	chr17	HAVANA	Gene	58982638	59106921	−	Protein coding	TRIM37
ENSG00000135406	0.042	1.35	chr12	HAVANA	Gene	49293252	49298686	+	Protein coding	PRPH
ENSG00000155846	0.043	0.75	chr5	HAVANA	Gene	1.5E+08	1.5E+08	+	Protein coding	PPARGC1B
ENSG00000008710	0.044	1.1	chr16	HAVANA	Gene	2088710	2135898	−	Protein coding	PKD1
ENSG00000119487	0.044	1.06	chr9	HAVANA	Gene	1.25E+08	1.26E+08	−	Protein coding	MAPKAP1
ENSG00000166033	0.044	1.01	chr10	HAVANA	Gene	1.22E+08	1.23E+08	+	Protein coding	HTRA1
ENSG00000091164	0.045	0.9	chr18	HAVANA	Gene	56597208	56651600	−	Protein coding	TXNL1
ENSG00000067445	0.046	1.51	chrX	HAVANA	Gene	54920462	54931431	+	Protein coding	TRO
ENSG00000081923	0.046	0.98	chr18	HAVANA	Gene	57646426	57803101	−	Protein coding	ATP8B1
ENSG00000138686	0.046	0.78	chr4	HAVANA	Gene	1.22E+08	1.22E+08	−	Protein coding	BBS7
ENSG00000138778	0.046	0.85	chr4	HAVANA	Gene	1.03E+08	1.03E+08	−	Protein coding	CENPE
ENSG00000142235	0.046	1.18	chr19	HAVANA	Gene	48485271	48513189	−	Protein coding	LMTK3
ENSG00000136052	0.048	0.91	chr12	HAVANA	Gene	1.05E+08	1.05E+08	−	Protein coding	SLC41A2
ENSG00000160714	0.048	1.03	chr1	HAVANA	Gene	1.55E+08	1.55E+08	−	Protein coding	UBE2Q1
ENSG00000179041	0.049	1.01	chr8	HAVANA	Gene	66429028	66430733	+	Protein coding	RRS1

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Identification of m6A-Related Biomarkers Associated with Prognosis of Colorectal Cancer

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