24 October 2021 : Clinical Research
Vitamin D Receptor Is a Sepsis-Susceptibility Gene in Chinese Children
Danni He12BCDEF, Xiuxiu Lu3ABCDEFG, Wei Li3BG, Yuanyuan Wang4BD, Ning Li3BC, Yuanmei Chen2CEG, Lipeng Zhang25EF, Wenquan Niu1AEF*, Qi Zhang2AEGDOI: 10.12659/MSM.932518
Med Sci Monit 2021; 27:e932518
Table 3 The unadjusted and adjusted risk prediction of 9 studied variants for sepsis mortality risk under additive and dominant models, respectively.
| Variants | Model | Additive model | Dominant model |
|---|---|---|---|
| rs9729 | Unadjusted | 1.02, 0.78–1.35, 0.87 | 1.02, 0.72–1.43, 0.93 |
| Adjusted | 1.06, 0.79–1.40, 0.71 | 1.06, 0.74–1.51, 0.76 | |
| rs2107301 | Unadjusted | 0.66, 0.50–0.87, 0.003 | 0.64, 0.45–0.90, 0.01 |
| Adjusted | 0.68, 0.51–0.91, 0.008 | 0.65, 0.46–0.93, 0.02 | |
| rs2189480 | Unadjusted | 0.64, 0.49–0.83, 0.001 | 0.58, 0.41–0.81, 0.002 |
| Adjusted | 0.64, 0.49–0.84, 0.001 | 0.58, 0.41–0.83, 0.003 | |
| rs2239185 | Unadjusted | 1.19, 0.90–1.56, 0.23 | 1.14, 0.82–1.60, 0.44 |
| Adjusted | 1.24, 0.93–1.65, 0.15 | 1.19, 0.84–1.69, 0.33 | |
| rs3782905 | Unadjusted | 0.74, 0.50–1.09, 0.13 | 0.77, 0.50–1.17, 0.21 |
| Adjusted | 0.77, 0.51–1.17, 0.22 | 0.79, 0.51–1.24, 0.31 | |
| rs4516035 | Unadjusted | 1.23, 0.57–2.62, 0.60 | 1.37, 0.61–3.06, 0.45 |
| Adjusted | 1.34, 0.59–3.01, 0.48 | 1.49, 0.62–3.55, 0.37 | |
| rs7139166 | Unadjusted | 1.16, 0.55–2.45, 0.70 | 1.28, 0.58–2.81, 0.55 |
| Adjusted | 1.28, 0.58–2.84, 0.55 | 1.41, 0.60–3.30, 0.43 | |
| rs11168266 | Unadjusted | 0.99, 0.76–1.28, 0.93 | 1.05, 0.75–1.47, 0.80 |
| Adjusted | 1.02, 0.78–1.34, 0.87 | 1.10, 0.77–1.56, 0.60 | |
| rs11168293 | Unadjusted | 1.09, 0.43–2.79, 0.86 | 1.09, 0.43–2.79, 0.86 |
| Adjusted | 1.24, 0.46–3.35, 0.68 | 1.24, 0.46–3.35, 0.68 | |
| Data are expressed as odds ratio, 95% confidence interval, value. The values were calculated after adjusting for age and sex in a logistic regression analysis. | |||