28 November 2021: Clinical Research
Diagnostic Accuracy of Intraoperative Intact Parathyroid Hormone Monitoring for Surgical Outcomes of Secondary Hyperparathyroidism
Yuanyuan Chen ABCDEF , Bin Liang ABCDEF , Xiaofeng Dong F , Tao Huang B , Tian-qi Liu AG*DOI: 10.12659/MSM.932556
Med Sci Monit 2021; 27:e932556
Table 2 Accuracy of different IO-iPTH prediction criteria.
| Criteria | Successful PTX | Persistent SHPT | Total | ||
|---|---|---|---|---|---|
| iPTH ≤314.5 pg/ml | TP93 | FP5 | 98 | ||
| iPTH >314.5 pg/ml | FN6 | TN15 | 21 | ||
| Total | 99 | 20 | 119 | ||
| Relative-iPTH ≤12.4% | TP90 | FP2 | 92 | ||
| Relative-iPTH >12.4% | FN9 | TN18 | 27 | ||
| Total | 99 | 20 | 119 | ||
| Relative-iPTH ≤12.4% or iPTH ≤314.5 pg/ml | TP97 | FP5 | 102 | ||
| Relative-iPTH >12.4% and iPTH >314.5 pg/ml | FN2 | TN15 | 17 | ||
| Total | 99 | 20 | 119 | ||
| Relative-iPTH ≤30.0% | TP99 | FP14 | 113 | ||
| Relative-iPTH >30.0% | FN0 | TN6 | 6 | ||
| Total | 99 | 20 | 119 | ||
| Paralleled standard in non-4-glands group | TP23 | FP3 | 26 | ||
| FN1 | TN11 | 12 | |||
| Total | 24 | 14 | 38 | ||
| iPTH ≤314.5 pg/ml | 93.9 (95% CI 0.750–0.892) | 75.0 (95% CI 0.506–0.904) | 94.9 (95% CI 0.879–0.981) | 71.4 (95% CI 0.477–0.878) | 90.8 (95% CI 0.841–0.949) |
| Relative-iPTH ≤12.4% | 90.9 (95% CI 0.830–0.955) | 90.0 (95% CI 0.668–0.982) | 97.8 (95% CI 0.916–0.996) | 66.7 (95% CI 0.460–0.827) | 90.8 (95% CI 0.841–0.949) |
| Paralleled standard | 97.8 (95% CI 0.922–0.996) | 75.0 (95% CI 0.506–0.904) | 95.1 (95% CI 0.884–0.982) | 88.2 (95% CI 0.623–0.979) | 94.1 (95% CI 0.882–0.973) |
| Relative iPTH ≤30.0% | 100 (95% CI 0.953–1.000) | 30 (95% CI 0.128–0.543) | 87.6 (95% CI 0.798–0.928) | 100 (95% CI 0.517–1) | 88.2 (95% CI 0.811–0.930) |
| Paralleled standard in non-4-glands group | 95.8 (95% CI 0.769–0.998) | 78.6 (95% CI 0.488–0.943) | 88.5 (95% CI 0.687–0.970) | 91.7 (95% CI 0.598–0.996) | 89.5 (95% CI 0.753–0.964) |
| TP – true positive; TN – true negative; FP – false positive; FN – false negative; PPV – positive predictive value; NPV – negative predictive value; paralleled standard – relative-iPTH ≤12.4% or iPTH ≤314.5 pg/ml. | |||||