01 December 2021: Clinical Research
A Retrospective Observational Study of the Association Between Plasma Levels of Interleukin 8 in 42 Patients with Sepsis-Induced Myocardial Dysfunction at a Single Center Between 2017 and 2020
XiaoYing Chen 1ABC , Xian Liu 1BE , RuiAn Dong 1BE , Dan Zhang 1AG** , Shu Qin 2AG**DOI: 10.12659/MSM.933065
Med Sci Monit 2021; 27:e933065
Table 1 Comparison of basic information and clinical characteristics between the 2 groups.
| Characteristics on admission | Total (n=256) | SIMD (n=42) | NO-SIMD (n=214) | P |
|---|---|---|---|---|
| Age, years | 66.00 (53.00, 74.00) | 67.50 (60.00, 77.25) | 66.00 (51.75, 74.00) | 0.105 |
| Male, n (%) | 158 (61.72%) | 21 (50.00%) | 137 (64.02%) | 0.087 χ |
| Need for vasoactive agents, n (%) | 48 (18.75%) | 17 (40.48%) | 31 (14.48%) | |
| Need for ventilation, n (%) | 86 (33.59%) | 17 (40.48%) | 69 (32.24%) | 0.302 χ |
| Arrhythmic complications, n (%) | 107 (41.80%) | 22 (52.38%) | 85 (39.72%) | 0.128 χ |
| Vital signs | ||||
| Temperature, °C | 37.22±0.98 | 37.28±1.18 | 37.20±0.94 | 0.645 |
| Pulse, beats/min | 103.64±24.74 | 102.64±21.34 | 103.84±25.40 | 0.775 |
| Respiratory rate, breaths/min | 25.17±7.51 | 21.54±7.56 | 25.17±7.52 | 0.981 |
| Mean arterial pressure, mm Hg | 96.63±22.45 | 91.64±17.32 | 97.37±24.95 | 0.588 |
| Glasgow Coma Scale | 14 (12,15) | 14 (13, 15) | 14 (12, 15) | 0.454 |
| Arterial blood gas analysis | ||||
| pH | 7.37±0.10 | 7.38±0.11 | 7.38±0.10 | 0.848 |
| PaO/FiO, mm Hg | 243.46±123.53 | 220.38±143.67 | 253.28±117.42 | 0.873 |
| PaCO, mm Hg | 40.00 (30.00,57.00) | 36.50 (29.08, 50.43) | 40.95 (30.00, 57.13) | 0.577 |
| Lactate, mmol/L | 1.82 (1.10, 3.23) | 2.45 (1.96, 4.78) | 1.58 (1.05, 2.75) | 0.001 |
| Blood routine | ||||
| White blood cell count, ×10/L | 12.55±7.79 | 12.28±5.98 | 12.60±8.10 | 0.807 |
| Neutrophil, % | 87.10 (82.20, 91.57) | 86.00 (82.75, 91.55) | 87.20 (81.80, 91.60) | 0.995 |
| Red blood cell count, ×10/L | 3.69±1.11 | 3.85±1.04 | 3.66±1.12 | 0.317 |
| Hemoglobin, g/L | 107.14±32.73 | 109.88±27.19 | 106.60±33.74 | 0.554 |
| Hematocrit,% | 33.66±10.04 | 34.25±10.04 | 33.55±10.06 | 0.677 |
| Biochemical indices | ||||
| Total bilirubin, μmol/L | 23.20 (15.58, 38.20) | 26.25 (15.75, 55.73) | 23.20 (15.45, 35.50) | 0.070 |
| Direct bilirubin, μmol/L | 12.30 (6.73, 21.43) | 16.40 (7.48, 29.30) | 11.95 (6.53, 18.30) | 0.127 |
| AST, U/L | 44.00 (25.00, 77.75) | 43.00 (28.00, 120.00) | 44.00 (24.00, 76.00) | 0.291 |
| ALT, U/L | 64.00 (30.00. 131.25) | 65.50 (41.75, 140.25) | 63.00 (27.50, 126.00) | 0.300 |
| BUN, mmol/L | 9.80 (6.23, 15.30) | 15.00 (11.10, 19.18) | 9.20 (5.98, 14.45) | |
| Creatinine, μmol/L | 97.00 (65.00, 151.00) | 134.50 (87.50, 236.75) | 91.00 (60.00, 135.00) | |
| Serum sodium, mmol/L | 142.26±8.62 | 143.95±8.06 | 141.93±8.71 | 0.164 |
| Serum potassium, mmol/L | 4.2 (3.8, 4.9) | 4.25 (3.875,4.925) | 4.20 (3.80, 4.90) | 0.354 |
| Procalcitonin, mmol/L | 1.34 (0.18, 8.71) | 4.40 (2.50, 23.67) | 0.84 (0.15, 5.66) | 0.001 |
| Cardiac biomarkers | ||||
| cTnT, ug/L | 0.0420 (0.0193, 0.1040) | 0.0945 (0.0405, 0.2133) | 0.0360 (0.0155, 0.0795) | |
| NT-proBNP, ng/L | 1828 (470, 5472) | 7782.00 (2601.50, 28415.50) | 1553.50 (422.00, 4228.00) | |
| APACHE II score | 17.03±7.17 | 18.06±6.74 | 16.31±9.16 | 0.251 |
| SOFA score | 8.0 (6.0, 12.0) | 8.0 (6.0, 12.0) | 8.0 (7.0, 12.0) | 0.647 |
| Length of stay, days | 10 (7, 22) | 10 (4, 17.50) | 10 (7, 22) | 0.331 |
| Mortality,% | 38 (14.84%) | 10 (23.81%) | 28 (13.08%) | 0.074 χ |
| SIMD – sepsis-induced myocardial dysfunction; NO-SIMD – without sepsis-induced myocardial dysfunction; APACHE II – Acute Physiology and Chronic Health Evaluation II; SOFA Score – Sepsis-related Organ Failure Assessment; AST – glutamic-oxaloacetic transaminase; ALT – glutamic-pyruvic transaminase; BUN – blood urea nitrogen; NT-proBNP – N terminal pro B type natriuretic peptide; cTnT – cardiac troponin T; χ – chi-squared analysis was used for the comparison between SIMD and NO-SIMD groups; – test was used for comparison between SIMD group and NO-SIMD group; – Mann-Whitney U test was used for comparison between SIMD group and NO-SIMD group. | ||||