Impact of Post-Mastectomy Radiation Therapy for Sentinel Lymph Node Micrometastases in Early-Stage Breast Cancer Patients

Hua Luo; Ou Ou Yang; Jun Ling He; Tian Lan

doi:10.12659/MSM.933275

30 January 2022 : Database Analysis

Impact of Post-Mastectomy Radiation Therapy for Sentinel Lymph Node Micrometastases in Early-Stage Breast Cancer Patients

Hua Luo^1ACDEF*, Ou Ou Yang^1BCF, Jun Ling He^1BCD, Tian Lan^1AD

DOI: 10.12659/MSM.933275

Med Sci Monit 2022; 28:e933275

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Table 2 Univariate and multivariate analyses of breast cancer-specific survival in unmatched and matched cohort.

Characteristics	Before PSM						After PSM
	5 year BCSS	Univariate		Multivariate			5 year BCSS	Univariate		Multivariate
	5 year BCSS	Chisq	P	HR	95%CI	P	5 year BCSS	Chisq	P	HR	95%CI	P
Age		2.609	0.106					0.244	0.622
<50	0.96			Reference			0.949			Reference
>50	0.946			1.17	0.81–1.7	0.397	0.961			0.67	0.39–1.18	0.165
Marital status		6.221	0.013					0.397	0.529
Married	0.957			Reference			0.961			Reference
Unmarried	0.939			1.46	1.06–2.02	0.02	0.948			1.15	0.66–2.03	0.617
Race		1.227	0.268					2.055	0.152
Non White	0.955			Reference			0.962			Reference
White	0.95			1.32	0.83–2.1	0.247	0.955			2.48	0.96–6.39	0.06
Median household income		6.27	0.099					5.659	0.129
Quartile 1	0.94			Reference			0.921			Reference
Quartile 2	0.966			1.01	0.74–1.37	0.968	0.956			0.70	0.41–1.17	0.171
Quartile 3	0.946			1.08	0.78–1.49	0.653	0.962			1.16	0.68–1.99	0.579
Quartile 4	0.953			0.63	0.45–0.89	0.008	0.98			0.64	0.36–1.13	0.121
T stage		21.9	<0.001					12.22	<0.001
T0/1	0.968			Reference			0.982			Reference
T2	0.929			1.89	1.37–2.62	<0.001	0.935			3.47	1.89–6.37	<0.001
Grade		42.439	<0.001					11.19	0.001
I+II	0.97			Reference			0.968			Reference
III	0.903			1.80	1.27–2.56	0.001	0.931			1.26	0.69–2.3	0.442
ER status		63.363	<0.001					30.08	<0.001
Negative	0.831			Reference			0.824			Reference
Positive	0.968			0.67	0.42–1.07	0.09	0.973			0.41	0.17–0.97	0.043
PR status		70.351	<0.001					22.29	<0.001
Negative	0.869			Reference			0.889			Reference
Positive	0.974			0.44	0.29–0.68	<0.001	0.975			0.45	0.21–0.97	0.042
Radiation		2.234	0.135					2.488	0.115
None/unknown	0.952			Reference			0.964			Reference
Yes	0.944			1.28	0.87–1.9	0.212	0.946			1.46	0.87–2.48	0.155
Chemotherapy		1.876	0.171					1.394	0.238
No/unknown	0.957			Reference			0.978			Reference
Yes	0.945			0.94	0.66–1.34	0.742	0.947			1.04	0.54–2	0.913
BCSS – breast cancer-specific survival; PSM – propensity score matching; HR – hazard ratio; CI – confidence interval.

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Impact of Post-Mastectomy Radiation Therapy for Sentinel Lymph Node Micrometastases in Early-Stage Breast Cancer Patients

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