Impact of Post-Mastectomy Radiation Therapy for Sentinel Lymph Node Micrometastases in Early-Stage Breast Cancer Patients

Hua Luo; Ou Ou Yang; Jun Ling He; Tian Lan

doi:10.12659/MSM.933275

30 January 2022 : Database Analysis

Impact of Post-Mastectomy Radiation Therapy for Sentinel Lymph Node Micrometastases in Early-Stage Breast Cancer Patients

Hua Luo^1ACDEF*, Ou Ou Yang^1BCF, Jun Ling He^1BCD, Tian Lan^1AD

DOI: 10.12659/MSM.933275

Med Sci Monit 2022; 28:e933275

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Table 3 Univariate and multivariate analyses of overall survival in unmatched and matched cohort.

Characteristics	Before PSM						After PSM
	5 year OS	Univariate		Multivariate			5 year OS	Univariate		Multivariate
	5 year OS	Chisq	P	HR	95%CI	P	5 year OS	Chisq	P	HR	95%CI	P
Age		50.288	<0.001					8.045	0.005
<50	0.954			Reference			0.944			Reference
>50	0.879			2.03	1.48–2.78	<0.001	0.918			1.39	0.87–2.22	0.168
Marital status		79.005	<0.001					9.054	0.003
Married	0.938			Reference			0.942			Reference
Unmarried	0.84			2.22	1.78–2.77	<0.001	0.896			1.48	0.98–2.22	0.061
Race		0.803	0.37					1.47	0.225
Non White	0.915			Reference			0.936			Reference
White	0.901			1.09	0.8–1.48	0.603	0.925			1.43	0.75–2.71	0.277
Median household income		8.782	0.032					12.242	0.007
Quartile 1	0.861			Reference			0.862			Reference
Quartile 2	0.919			0.87	0.7–1.07	0.197	0.931			0.64	0.44–0.94	0.022
Quartile 3	0.91			1.15	0.92–1.43	0.212	0.953			1.39	0.92–2.08	0.115
Quartile 4	0.92			0.86	0.68–1.08	0.188	0.954			0.86	0.55–1.34	0.503
T stage		25.135	<0.001					15.59	<0.001
T0/1	0.925			Reference			0.964			Reference
T2	0.876			1.69	1.35–2.11	<0.001	0.897			2.78	1.79–4.31	<0.001
Grade		17.861	<0.001					7.583	0.006
I+II	0.917			Reference			0.94			Reference
III	0.867			1.44	1.12–1.84	0.005	0.899			1.37	0.87–2.16	0.169
ER status		25.656	<0.001					21.061	<0.001
Negative	0.788			Reference			0.785			Reference
Positive	0.919			0.77	0.54–1.09	0.141	0.946			0.44	0.22–0.87	0.018
PR status		45.864	<0.001					16.306	<0.001
Negative	0.814			Reference			0.858			Reference
Positive	0.928			0.60	0.44–0.8	0.001	0.947			0.66	0.37–1.17	0.154
Radiation		0.531	0.466					1.056	0.304
None/unknown	0.901			Reference			0.939			Reference
Yes	0.912			1.07	0.78–1.45	0.686	0.912			1.27	0.85–1.89	0.243
Chemotherapy		31.872	<0.001					13.02	<0.001
No/unknown	0.877			Reference			0.914			Reference
Yes	0.929			0.55	0.43–0.7	<0.001	0.933			0.41	0.26–0.62	<0.001
OS – overall survivall; PSM – propensity score matching; HR – hazard ratio; CI – confidence interval.

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Impact of Post-Mastectomy Radiation Therapy for Sentinel Lymph Node Micrometastases in Early-Stage Breast Cancer Patients

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