Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons

Jiangyuan Qin; Tingjia Wei; Huiying Chen; Xiaoyu Lin; Danxue Qin; Fangyu Wei; Peiqiang Liu; Wenhua Ye; Jiping Su

doi:10.12659/MSM.933278

18 October 2021 : Laboratory Research

Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons

Jiangyuan Qin^1ABCDEF, Tingjia Wei^1BCD, Huiying Chen^1BCD, Xiaoyu Lin^1BC, Danxue Qin^1BC, Fangyu Wei^1BC, Peiqiang Liu^1BC, Wenhua Ye^1BC, Jiping Su^1ADG*

DOI: 10.12659/MSM.933278

Med Sci Monit 2021; 27:e933278

Authors information Article notes Copyright and License information

Background Material and Methods Results Discussion Conclusions References

Related articles Order reprints Share article Share by email

View HTML version

Table 1 Drug treatment groups.

Inhibiting endocytosis	Inhibiting PKC
Ctrl	Ctrl
SKF	SKF
SKF+SCH	SKF+SCH
Dynasore	Bis I
SKF+Dynasore	SKF+Bis I
SKF+SCH+Dynasore	SKF+SCH+Bis I
SS	SS
SS+SKF	SS+SKF
SS+SKF+SCH	SS+SKF+SCH
SS+Dynasore	SS+Bis I
SS+SKF+Dynasore	SS+SKF+Bis I
SS+SKF+SCH+Dynasore	SS+SKF+SCH+Bis I
Ctrl – control; SKF – SKF38393, D1R agonist, 20 μM, MCE, USA; SCH – SCH23390, D1R antagonist, 20 μM, MCE, USA; Dynasore – clathrin/dynamin-mediated endocytosis inhibitor, 80 μM, Sigma, USA; SS – 5 mM, Sigma, USA; Bis I – Bisindolylmaleimide I, selective PKC antagonist, 4 μM, MCE, USA.

Back to the Article

Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons

Your Privacy