18 October 2021 : Laboratory Research
Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons
Jiangyuan Qin1ABCDEF, Tingjia Wei1BCD, Huiying Chen1BCD, Xiaoyu Lin1BC, Danxue Qin1BC, Fangyu Wei1BC, Peiqiang Liu1BC, Wenhua Ye1BC, Jiping Su1ADG*DOI: 10.12659/MSM.933278
Med Sci Monit 2021; 27:e933278
Supplementary Table 1 Data of Figure 2, GABARγ2 protein expression in the absence or presence of dynasore.
| Groups | Density (mean±SD) | Relative expression as % of control (mean±SD) | ||||
|---|---|---|---|---|---|---|
| Surface GABARγ2 | Surface Flotillin-1 | Total GABARγ2 | Total βIII-tubulin | Surface GABARγ2 | Total GABARγ2 | |
| Ctrl | 138.47±29.11 | 196.57±11.34 | 100.95±13.51 | 197.86±4.28 | 100±0.00 | 100±0.00 |
| SKF | 72.09±19.13 | 209.35±10.51 | 101.34±5.24 | 200.21±20.37 | 48.57±7.12 | 100.53±28.99 |
| SKF+SCH | 141.36±21.36 | 194.75±5.37 | 102.69±9.03 | 206.96±10.07 | 103.79±5.69 | 98.58±28.59 |
| Dynasore | 139.43±15.05 | 199.91±7.64 | 107.51±9.91 | 206.27±15.85 | 99.77±13.03 | 103.21±31.09 |
| SKF+Dynasore | 123.07±22.19 | 186.04±14.32 | 116.57±6.47 | 199.87±14.63 | 94.44±7.24 | 115.66±36.49 |
| SKF+SCH+Dynasore | 125.56±7.11 | 188.29±17.55 | 107.77±8.66 | 208.61±11.38 | 94.57±13.83 | 102.90±35.77 |
| Ctrl | 103.04±17.51 | 112.93±11.65 | 119.81±21.26 | 159.16±33.16 | 100±0.00 | 100±0.00 |
| SS | 52.76±20.82 | 121.77±12.96 | 126.28±10.11 | 131.89±34.01 | 47.15±11.11 | 127.97±56.15 |
| SS+SKF | 54.89±19.24 | 135.92±18.99 | 119.76±7.12 | 136.72±36.37 | 44.76±7.18 | 117.06±41.60 |
| SS+SKF+SCH | 101.31±16.04 | 146.16±22.45 | 120.72±24.93 | 134.21±36.61 | 76.56±1.43 | 120.25±50.28 |
| SS+Dynasore | 127.41±24.80 | 122.01±21.27 | 106.53±16.60 | 130.01±30.71 | 115.19±22.57 | 109.43±35.46 |
| SS+SKF+Dynasore | 127.53±21.77 | 123.06±32.65 | 117.21±7.79 | 140.48±39.40 | 114.30±7.02 | 112.58±35.96 |
| SS+SKF+SCH+Dynasore | 136.35±14.02 | 130.11±28.63 | 105.01±11.70 | 131.24±37.08 | 115.52±9.36 | 107.66±7.16 |