18 December 2021 : Clinical Research
Age-Stratified Cut-Off Values for Serum Levels of N-Terminal ProB-Type Natriuretic Peptide and Mortality from Sepsis in Children Under Age 18 Years: A Retrospective Study from a Single Center
Yan-na Sun1ABCE, Chun-wang Lin1ABCDEF*, Wen Tang2BF, Jiang-ping Zhang1CFDOI: 10.12659/MSM.933400
Med Sci Monit 2021; 27:e933400
Table 4 ROC analysis of serum NT-proBNP levels for short-term mortality prediction in septic children of different ages.
| Patients with sepsis | <1 year | 1–3 years | 4–6 years | 7–18 years |
|---|---|---|---|---|
| Subjects, n | 85 | 139 | 56 | 47 |
| AUC (95% CI) | 0.815 (0.73–0.93) | 812 (0.69–0.92) | 0.806 (0.66–0.91) | 0.725 (0.62–0.91) |
| Sensitivity | 0.786 | 0.807 | 0.814 | 0.847 |
| Specificity | 0.937 | 0.915 | 0.882 | 0.837 |
| Optimal cut-off, ng/L | 5000 | 4500 | 4100 | 3800 |
| Positive likelihood ratio | 21.6 | 17.3 | 20.2 | 19.7 |
| NT-proBNP – N-terminal fragment of proB-type natriuretic peptide; AUC – area under the ROC curve. | ||||