Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

04 January 2022: Animal Study

Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

Kun Cao 12BCEF , Jie Xiang 13CF , Yang-Ting Dong 34BCD , Yi Xu 13CD , Zhi-Zhong Guan 134ADG*

DOI: 10.12659/MSM.933978

Med Sci Monit 2022; 28:e933978

Table 2 The content of MDA and activities of SOD and GSH-Px in the brains of mice at 6 months of age.

GroupnMDA (nmol/mgprot)SOD (U/mg prot)GSH-Px (kU/L)
WT103.61±0.2335.4±0.75659±32.01
APP/PS1105.48±0.34** 23.3±0.44** 436±18.0**
APP/PS1+PUN-282987103.72±0.49## 37.9±1.61## 655±56.4##
WT – wild-type; APP/PS1 – amyloid precursor protein/presenilin 1; pr – protein; SOD – superoxide dismutase; GSH-Px – glutathione peroxidase. The values presented are means±standerd deviation.
*
**
#
##

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750