Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

04 January 2022 : Animal Research

Kun Cao^12BCEF, Jie Xiang^13CF, Yang-Ting Dong^34BCD, Yi Xu^13CD, Zhi-Zhong Guan^134ADG*

DOI: 10.12659/MSM.933978

Med Sci Monit 2022; 28:e933978

Background Material and Methods Results Discussion Conclusions References

Related articles Order reprints Share article Share by email

View HTML version

Table 2 The content of MDA and activities of SOD and GSH-Px in the brains of mice at 6 months of age.

Group	n	MDA (nmol/mgprot)	SOD (U/mg prot)	GSH-Px (kU/L)
WT	10	3.61±0.23	35.4±0.75	659±32.01
APP/PS1	10	5.48±0.34^**	23.3±0.44^**	436±18.0^**
APP/PS1+PUN-282987	10	3.72±0.49^##	37.9±1.61^##	655±56.4^##
WT – wild-type; APP/PS1 – amyloid precursor protein/presenilin 1; pr – protein; SOD – superoxide dismutase; GSH-Px – glutathione peroxidase. The values presented are means±standerd deviation. ^* ^** ^# ^##

Back to the Article