Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

04 January 2022 : Animal Research

Kun Cao^12BCEF, Jie Xiang^13CF, Yang-Ting Dong^34BCD, Yi Xu^13CD, Zhi-Zhong Guan^134ADG*

DOI: 10.12659/MSM.933978

Med Sci Monit 2022; 28:e933978

Background Material and Methods Results Discussion Conclusions References

Related articles Order reprints Share article Share by email

View HTML version

Table 3 The content of MDA and activities of SOD and GSH-Px in the brains of mice at 10 months of age.

Group	n	MDA (nmol/mgprot)	SOD (U/mg prot)	GSH-Px (kU/L)
WT	10	3.37±0.37	35.1±2.48	641±51.5
APP/PS1	10	5.77±0.16^**	16.5±2.01^**	335±15.9^**
APP/PS1+PUN-282987	10	3.99±0.46,^*	32.2±2.28^##	650±41.5^##
WT – wild-type; APP/PS1 – amyloid precursor protein/presenilin 1; pr – protein; SOD – superoxide dismutase; GSH-Px – glutathione peroxidase. The values presented are means±standerd deviation. ^* ^** ^# ^##

Back to the Article