Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

04 January 2022 : Animal Research

Kun Cao^12BCEF, Jie Xiang^13CF, Yang-Ting Dong^34BCD, Yi Xu^13CD, Zhi-Zhong Guan^134ADG*

DOI: 10.12659/MSM.933978

Med Sci Monit 2022; 28:e933978

Background Material and Methods Results Discussion Conclusions References

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Table 5 The content of MDA and activities of SOD and GSH-Px in the serum of mice at 10 months of age.

Group	n	MDA (nmol/mgprot)	SOD (U/mg prot)	GSH-Px (kU/L)
WT	10	1.72±0.91	88.9±2.72	720±3.86
APP/PS1	10	8.06±0.76^**	58.3±4.39^**	506±19.3^**
APP/PS1+PUN-282987	10	2.74±0.99^##	81.1±1.94,^*	688±16.3,^*
WT – wild-type; APP/PS1 – amyloid precursor protein/presenilin 1; pr – protein; SOD – superoxide dismutase; GSH-Px – glutathione peroxidase. The values presented are means±standard deviation. ^* ^** ^# ^##

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