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04 January 2022: Animal Study

Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

Kun Cao 12BCEF , Jie Xiang 13CF , Yang-Ting Dong 34BCD , Yi Xu 13CD , Zhi-Zhong Guan 134ADG*

DOI: 10.12659/MSM.933978

Med Sci Monit 2022; 28:e933978

Table 5 The content of MDA and activities of SOD and GSH-Px in the serum of mice at 10 months of age.

GroupnMDA (nmol/mgprot)SOD (U/mg prot)GSH-Px (kU/L)
APP/PS1108.06±0.76** 58.3±4.39** 506±19.3**
APP/PS1+PUN-282987102.74±0.99## 81.1±1.94,* 688±16.3,*
WT – wild-type; APP/PS1 – amyloid precursor protein/presenilin 1; pr – protein; SOD – superoxide dismutase; GSH-Px – glutathione peroxidase. The values presented are means±standard deviation.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750