11 January 2022: Clinical Research
Association Between Hyperhomocysteinemia Combined with Metabolic Syndrome and Higher Prevalence of Stroke in Chinese Adults Who Have Elevated Blood Pressure
Feng Hu 12BCDEF , Shichao Yu 3BCD , Juan Li 4ABCD , Wei Zhou 25BDEF , Tao Wang 25BCDE , Xiao Huang 125AF , Huihui Bao 125AG* , Xiaoshu Cheng 125AG*DOI: 10.12659/MSM.934100
Med Sci Monit 2022; 28:e934100
Table 2 Relationship between plasma tHcy levels or MS and the prevalence of stroke in different models.
| Variables | Event, n (%) | Crude Model | Model I | Model II | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | ||
| tHcy (μmol/L) | |||||||
| Per SD increase | 960 (6.83%) | 1.18 (1.12, 1.23) | 1.13 (1.07, 1.19) | 1.08 (1.02, 1.14) | 0.010a | ||
| tHcy (μmol/L) | |||||||
| 367 (5.22%) | Ref | Ref | Ref | ||||
| ≥15 | 593 (8.44%) | 1.68 (1.46, 1.92) | 1.48 (1.28, 1.71) | 1.36 (1.17, 1.58) | a | ||
| tHCY tertile (μmol/L) | |||||||
| T1 [5.88, 13.23] | 231 (4.93%) | Ref | Ref | Ref | |||
| T2 [13.24, 17.37] | 307 (6.54%) | 1.35 (1.13, 1.61) | 1.24 (1.04, 1.49) | 0.017 | 1.28 (1.06, 1.53) | 0.009b | |
| T3 [17.38, 134.50] | 422 (9.00%) | 1.91 (1.62, 2.25) | 1.62 (1.36, 1.94) | 1.49 (1.23, 1.81) | b | ||
| tHcy quartile (μmol/L) | |||||||
| Q1 [5.88, 12.46] | 176 (5.02%) | Ref | Ref | Ref | |||
| Q2 [12.47, 15.00] | 191 (5.41%) | 1.08 (0.88, 1.34) | 0.459 | 1.01 (0.82, 1.25) | 0.922 | 1.04 (0.84, 1.29) | 0.709c |
| Q3 [15.01, 19.11] | 268 (7.60%) | 1.56 (1.28, 1.89) | 1.38 (1.13, 1.69) | 0.002 | 1.37 (1.11, 1.69) | 0.003c | |
| Q4 [19.12, 134.50] | 326 (9.27%) | 1.93 (1.60, 2.34) | 1.61 (1.31, 1.97) | 1.49 (1.19, 1.85) | c | ||
| P for trend | |||||||
| MS | |||||||
| No | 490 (6.03%) | Ref | Ref | Ref | |||
| Yes | 470 (7.92%) | 1.34 (1.18, 1.53) | 1.58 (1.38, 1.81) | 1.68 (1.44, 1.96) | d | ||
| No. of MS components | |||||||
| One | 256 (6.32%) | Ref | Ref | Ref | |||
| Two | 234 (5.75%) | 0.90 (0.75, 1.09) | 0.278 | 1.01 (0.84, 1.21) | 0.935 | 1.09 (0.90, 1.32) | 0.394e |
| Three | 257 (7.53%) | 1.21 (1.01, 1.44) | 0.039 | 1.47 (1.22, 1.77) | 1.74 (1.41, 2.13) | e | |
| Four | 158 (7.97%) | 1.28 (1.04, 1.58) | 0.018 | 1.64 (1.32, 2.03) | 1.99 (1.56, 2.54) | e | |
| Five | 55 (10.22%) | 1.69 (1.24, 2.29) | 2.22 (1.62, 3.04) | 2.60 (1.84, 3.67) | e | ||
| P for trend | |||||||
| tHcy – total homocysteine; MS – metabolic syndrome; Ref – reference; OR – odds ratio; CI confidence interval; SD – standard deviation. Model I adjusted for age and sex. Model II: a adjusted for sex, smoking and drinking status, eGFR, reduced HDL-C and abdominal obesity. b adjusted for + serum uric acid. c adjusted for + age and elevated TG. d adjusted for age, sex, BMI, smoking and drinking status, eGFR and tHcy. e adjusted for + heart rate and serum uric acid. | |||||||