11 January 2022: Clinical Research
Association Between Hyperhomocysteinemia Combined with Metabolic Syndrome and Higher Prevalence of Stroke in Chinese Adults Who Have Elevated Blood Pressure
Feng Hu 12BCDEF , Shichao Yu 3BCD , Juan Li 4ABCD , Wei Zhou 25BDEF , Tao Wang 25BCDE , Xiao Huang 125AF , Huihui Bao 125AG* , Xiaoshu Cheng 125AG*DOI: 10.12659/MSM.934100
Med Sci Monit 2022; 28:e934100
Table 3 Effect size of combined HHcy and MS on the prevalence of stroke in different models compared to its isolated forms.
| Variables | Crude Model | Model I | Model II | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| Isolated HHcy | Ref | Ref | Ref | |||
| HHcy+MS | 1.36 (1.15, 1.61) | 1.57 (1.32, 1.87) | 1.78 (1.47, 2.15) | |||
| Isolated MS | Ref | Ref | Ref | |||
| HHcy+MS | 1.68 (1.39, 2.03) | 1.47 (1.21, 1.78) | 1.39 (1.13, 1.70) | 0.002 | ||
| HHcy – hyperhomocysteinemia; MS – metabolic syndrome; Ref – reference; OR – odds ratio; CI – confidence interval. Model I adjusted for age and sex. Model II adjusted for sex, BMI, smoking and drinking status, eGFR and serum uric acid. | ||||||