11 January 2022 : Clinical Research
Association Between Hyperhomocysteinemia Combined with Metabolic Syndrome and Higher Prevalence of Stroke in Chinese Adults Who Have Elevated Blood Pressure
Feng Hu12BCDEF, Shichao Yu3BCD, Juan Li4ABCD, Wei Zhou25BDEF, Tao Wang25BCDE, Xiao Huang125AF*, Huihui Bao125AG, Xiaoshu Cheng125AGDOI: 10.12659/MSM.934100
Med Sci Monit 2022; 28:e934100
Supplementary Table 1 Associations of covariates with stroke occurrence.
| Covariates | OR (95% CI) | P value |
|---|---|---|
| Age (years) | 1.01 (1.01, 1.02) | |
| Sex | ||
| Male | Ref | |
| Female | 0.63 (0.55, 0.72) | |
| BMI (kg/m) | 0.99 (0.97, 1.00) | 0.124 |
| Heart rate (times/min) | 1.00 (0.99, 1.00) | 0.227 |
| Smoking status, n (%) | ||
| Never | Ref | |
| Former smoker | 1.95 (1.66, 2.29) | |
| Current smoker | 1.16 (0.99, 1.36) | 0.068 |
| Drinking status, n (%) | ||
| Never | Ref | |
| Former drinker | 1.85 (1.58, 2.18) | |
| Current drinker | 0.50 (0.41, 0.62) | |
| tHcy (μmol/L) | 1.01 (1.01, 1.02) | |
| Serum uric acid (mmol/L) | 1.00 (1.00, 1.00) | 0.329 |
| eGFR (ml/min) | 0.99 (0.99, 0.99) | |
| Total bilirubin (mmol/L) | 0.99 (0.98, 1.00) | 0.255 |
| Direct bilirubin (mmol/L) | 1.00 (0.98, 1.03) | 0.900 |
| AST (U/L) | 1.00 (1.00, 1.00) | 0.372 |
| ALT (U/L) | 1.00 (1.00, 1.01) | 0.183 |
| Abdominal obesity, n (%) | ||
| No | Ref | 0.010 |
| Yes | 0.83 (0.72, 0.96) | |
| Hyperglycemia, n (%) | ||
| No | Ref | |
| Yes | 1.02 (0.89, 1.17) | 0.774 |
| Elevated TG, n (%) | ||
| No | Ref | |
| Yes | 1.30 (1.14, 1.48) | |
| Reduced HDL-C, n (%) | ||
| No | Ref | |
| Yes | 2.07 (1.80, 2.39) | |
| BMI – body mass index; tHcy – total homocysteine; TC – total cholesterol; HDL-C – high-density lipoprotein cholesterol; eGFR – estimated glomerular filtration rate; AST – aspartate aminotransferase; ALT – alanine aminotransferase; T2DM – type 2 diabetes mellitus; Ref reference; OR – odds ratio; CI – confidence interval. Values are regression coefficients [OR (95% CI)] from univariate regression models and reflect differences in stroke occur per unit change of each covariate and for different categories of each covariate as compared to the reference group. | ||