11 January 2022: Clinical Research
Association Between Hyperhomocysteinemia Combined with Metabolic Syndrome and Higher Prevalence of Stroke in Chinese Adults Who Have Elevated Blood Pressure
Feng Hu 12BCDEF , Shichao Yu 3BCD , Juan Li 4ABCD , Wei Zhou 25BDEF , Tao Wang 25BCDE , Xiao Huang 125AF , Huihui Bao 125AG* , Xiaoshu Cheng 125AG*DOI: 10.12659/MSM.934100
Med Sci Monit 2022; 28:e934100
Supplementary Table 1 Associations of covariates with stroke occurrence.
| Covariates | OR (95% CI) | P value |
|---|---|---|
| Age (years) | 1.01 (1.01, 1.02) | |
| Sex | ||
| Male | Ref | |
| Female | 0.63 (0.55, 0.72) | |
| BMI (kg/m) | 0.99 (0.97, 1.00) | 0.124 |
| Heart rate (times/min) | 1.00 (0.99, 1.00) | 0.227 |
| Smoking status, n (%) | ||
| Never | Ref | |
| Former smoker | 1.95 (1.66, 2.29) | |
| Current smoker | 1.16 (0.99, 1.36) | 0.068 |
| Drinking status, n (%) | ||
| Never | Ref | |
| Former drinker | 1.85 (1.58, 2.18) | |
| Current drinker | 0.50 (0.41, 0.62) | |
| tHcy (μmol/L) | 1.01 (1.01, 1.02) | |
| Serum uric acid (mmol/L) | 1.00 (1.00, 1.00) | 0.329 |
| eGFR (ml/min) | 0.99 (0.99, 0.99) | |
| Total bilirubin (mmol/L) | 0.99 (0.98, 1.00) | 0.255 |
| Direct bilirubin (mmol/L) | 1.00 (0.98, 1.03) | 0.900 |
| AST (U/L) | 1.00 (1.00, 1.00) | 0.372 |
| ALT (U/L) | 1.00 (1.00, 1.01) | 0.183 |
| Abdominal obesity, n (%) | ||
| No | Ref | 0.010 |
| Yes | 0.83 (0.72, 0.96) | |
| Hyperglycemia, n (%) | ||
| No | Ref | |
| Yes | 1.02 (0.89, 1.17) | 0.774 |
| Elevated TG, n (%) | ||
| No | Ref | |
| Yes | 1.30 (1.14, 1.48) | |
| Reduced HDL-C, n (%) | ||
| No | Ref | |
| Yes | 2.07 (1.80, 2.39) | |
| BMI – body mass index; tHcy – total homocysteine; TC – total cholesterol; HDL-C – high-density lipoprotein cholesterol; eGFR – estimated glomerular filtration rate; AST – aspartate aminotransferase; ALT – alanine aminotransferase; T2DM – type 2 diabetes mellitus; Ref reference; OR – odds ratio; CI – confidence interval. Values are regression coefficients [OR (95% CI)] from univariate regression models and reflect differences in stroke occur per unit change of each covariate and for different categories of each covariate as compared to the reference group. | ||