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11 January 2022: Clinical Research

Association Between Hyperhomocysteinemia Combined with Metabolic Syndrome and Higher Prevalence of Stroke in Chinese Adults Who Have Elevated Blood Pressure

Feng Hu 12BCDEF , Shichao Yu 3BCD , Juan Li 4ABCD , Wei Zhou 25BDEF , Tao Wang 25BCDE , Xiao Huang 125AF , Huihui Bao 125AG* , Xiaoshu Cheng 125AG*

DOI: 10.12659/MSM.934100

Med Sci Monit 2022; 28:e934100

Supplementary Table 3 Effect size of HHcy and MS on cerebral stroke in different models.

VariablesEvent, n (%)Crude ModelModel IModel II
OR (95% CI)P-valueOR (95% CI)P-valueOR (95% CI)P-value
Control175 (4.48%)RefRefRef
Isolated HHcy315 (7.47%)1.72 (1.43, 2.08)1.44 (1.19, 1.76)1.32 (1.07, 1.62)0.008
Isolated MS192 (6.14%)1.40 (1.13, 1.72)0.0021.54 (1.25, 1.91)1.78 (1.41, 2.23)
HHcy+MS278 (9.90%)2.34 (1.93, 2.85)2.26 (1.86, 2.75)2.46 (1.97, 3.08)
P for trend
HHcy – hyperhomocysteinemia; MS – metabolic syndrome; Ref – reference; OR – odds ratio; CI – confidence interval. Model I adjusted for age and sex. Model II adjusted for sex, BMI, smoking and drinking status, eGFR, and serum uric acid.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750