30 October 2021 : Database Analysis
Construction and Verification of a Hypoxia-Stemness-Based Gene Signature for Risk Stratification in Esophageal Cancer
Kang Tang1BCDE, Yong Cheng2AF, Qian Li3AF*DOI: 10.12659/MSM.934359
Med Sci Monit 2021; 27:e934359
Table 2 Univariate analysis of expression of 14 hypoxia-stemness base prognostic genes with overall survival.
| Gene symbol | Univariate z score | HR | 95% CI | P value |
|---|---|---|---|---|
| GAS1 | 3.024 | 1.449 | (1.139, 1.842) | 0.002 |
| FABP1 | 2.973 | 1.331 | (1.102, 1.607) | 0.003 |
| EPCAM | 2.457 | 1.364 | (1.065, 1.748) | 0.014 |
| ARSE | 2.456 | 1.326 | (1.059, 1.661) | 0.014 |
| CLDN3 | 2.438 | 1.334 | (1.058, 1.682) | 0.015 |
| AMTN | 2.304 | 1.215 | (1.029, 1.433) | 0.021 |
| CYP2W1 | 2.294 | 1.251 | (1.033, 1.514) | 0.022 |
| IL17RB | 2.259 | 1.274 | (1.033, 1.572) | 0.024 |
| CLRN3 | 2.193 | 1.330 | (1.031, 1.717) | 0.028 |
| CLDN7 | 2.079 | 1.287 | (1.015, 1.633) | 0.038 |
| FOXA2 | 2.017 | 1.284 | (1.007, 1.638) | 0.044 |
| HHLA2 | 2.000 | 1.238 | (1.004, 1.527) | 0.046 |
| FBLN2 | −1.980 | 0.691 | (0.480, 0.996) | 0.048 |
| CTSF | 1.980 | 1.264 | (1.002, 1.594) | 0.048 |
| HR – hazard ratio risk; CI – confidence interval. | ||||