30 October 2021>: Database Analysis
Construction and Verification of a Hypoxia-Stemness-Based Gene Signature for Risk Stratification in Esophageal Cancer
Kang Tang 1BCDE , Yong Cheng 2AF , Qian Li 3AF*DOI: 10.12659/MSM.934359
Med Sci Monit 2021; 27:e934359
Table 3 Univariate and multivariate Cox regression analysis of clinicopathological characteristics associated with overall survival in the TCGA-ESCA cohort.
Variables | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Gender | 2.354 (0.728, 7.605) | 0.153 | – | – |
Stage | 2.671 (1.800, 3.964) | * | 1.582 (0.593, 4.220) | 0.359 |
T stage | 1.257 (0.866, 1.824) | 0.228 | – | – |
N stage | 1.819 (1.294, 2.556) | * | 1.580 (0.887, 2.815) | 0.120 |
M stage | 4.847 (2.211, 10.626) | * | 2.551 (0.413, 15.742) | 0.313 |
Risk score | 3.346 (2.054, 5.452) | * | 4.172 (2.429, 7.165) | * |
HR – hazard ratio; CI – confidence interval. * Statistically significant. |