02 April 2022: Clinical Research
Impact of Primary Tumor Resection on Survival of Patients with Metastatic Gallbladder Carcinoma: A Population-Based, Propensity Matched Study
Jiang Xie E* , Zuofu Liao C* , Chao Sun A , Zhonghao Chen AF*DOI: 10.12659/MSM.934447
Med Sci Monit 2022; 28:e934447
Table 4 Univariate Cox regression analysis for assessing the effect of different clinical variables on gallbladder cancer patients’ overall survival and disease-free survival in the matched population.
| Variables | OS | CSS | ||
|---|---|---|---|---|
| HR | P value | HR | P value | |
| Female | Reference | Reference | ||
| Male | 1.048 (0.834–1.316) | 0.688 | 1.036 (0.820–1.307) | 0.769 |
| Black | Reference | Reference | ||
| White | 0.976 (0.718–1.328) | 0.878 | 1.013 (0.738–1.391) | 0.935 |
| Other | 0.802 (0.522–1.233) | 0.314 | 0.787 (0.504–1.230) | 0.294 |
| ≤65 | Reference | Reference | ||
| >65 | 1.096 (0.889–1.351) | 0.393 | 1.074 (0.868–1.330) | 0.510 |
| Unmarried | Reference | Reference | ||
| Married | 0.754 (0.605–0.939) | 0.012 | 0.744 (0.595–0.931) | 0.010 |
| Unknown | 1.097 (0.706–1.703) | 0.681 | 1.064 (0.675–1.676) | 0.790 |
| I | Reference | Reference | ||
| II | 0.699 (0.381–1.285) | 0.250 | 0.668 (0.363–1.230) | 0.195 |
| III | 1.034 (0.574–1.861) | 0.912 | 0.995 (0.552–1.793) | 0.986 |
| IV | 2.023 (0.932–4.393) | 0.075 | 2.024 (0.932–4.396) | 0.075 |
| Unknown | 0.939 (0.513–1.718) | 0.838 | 0.895 (0.489–1.641) | 0.721 |
| T1 | Reference | Reference | ||
| T2 | 1.122 (0.564–2.233) | 0.744 | 1.162 (0.582–2.319) | 0.670 |
| T3 | 0.863 (0.628–1.187) | 0.365 | 0.852 (0.615–1.180) | 0.335 |
| T4 | 0.616 (0.366–1.035) | 0.068 | 0.640 (0.379–1.080) | 0.094 |
| Unknown | 0.979 (0.606–1.580) | 0.930 | 0.976 (0.599–1.591) | 0.923 |
| N0 | Reference | Reference | ||
| N1 | 0.910 (0.712–1.163) | 0.450 | 0.903 (0.703–1.161) | 0.427 |
| N2 | 0.898 (0.656–1.231) | 0.504 | 0.920 (0.669–1.266) | 0.608 |
| Unknown | 1.499 (1.039–2.164) | 0.031 | 1.521 (1.048–2.209) | 0.027 |
| None/Unknown | Reference | Reference | ||
| Yes | 0.594 (0.410–0.861) | 0.006 | 0.624 (0.431–0.905) | 0.013 |
| No/Unknown | Reference | Reference | ||
| Yes | 0.494 (0.397–0.616) | 0.484 (0.388–0.606) | ||
| No | Reference | Reference | ||
| Yes | 0.620 (0.502–0.766) | 0.614 (0.495–0.762) | ||
| ≤1 | Reference | Reference | ||
| ≤3 | 0.904 (0.465–1.757) | 0.766 | 0.839 (0.430–1.640) | 0.609 |
| ≤5 | 1.064 (0.556–2.037) | 0.852 | 1.025 (0.534–1.967) | 0.940 |
| >5 | 0.867 (0.460–1.632) | 0.658 | 0.836 (0.444–1.577) | 0.581 |
| Unknown | 1.110 (0.603–2.044) | 0.738 | 1.070 (0.580–1.971) | 0.829 |
| Adenocarcinomas | Reference | Reference | ||
| Epithelial | 1.129 (0.794–1.606) | 0.498 | 1.145 (0.801–1.637) | 0.456 |
| Mucinous | 1.052 (0.681–1.625) | 0.821 | 1.000 (0.634–1.577) | 0.999 |
| Others | 1.282 (0.748–2.196) | 0.367 | 1.336 (0.779–2.291) | 0.292 |