14 April 2022 : Database Analysis
Impact of Low-density Lipoprotein Cholesterol Levels on Outcomes in Nonvalvular Atrial Fibrillation: Results from the China Atrial Fibrillation Registry Study
Zhi-Zhao Li12ABCDEF*, Xin Du2A, Nian Liu2A, Xue-yuan Guo2A, Chao Jiang2A, Liu He2C, Shi-jun Xia2A, Wei Wang2A, Ri-bo Tang2A, San-shuai Chang2A, Rong-hui Yu2A, De-yong Long2A, Rong Bai2A, Cai-hua Sang2A, Song-nan Li2A, Jian-zeng Dong2A, Chang-sheng Ma2ADOI: 10.12659/MSM.934747
Med Sci Monit 2022; 28:e934747
Table 2 Univariate and multivariate cox regression models for risk of stroke/thromboembolism and cardiovascular mortality among patients with atrial fibrillation.
| Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Statin use | 1.29 | (1.1, 1.5) | 0.002 | 0.96 | (0.82,1.14) | 0.668 |
| Age, per y | 1.06 | (1.05, 1.07) | <.0001 | 1.04 | (1.03,1.05) | <.0001 |
| Sex, Male | 0.92 | (0.79, 1.08) | 0.317 | 1.10 | (0.93,1.3) | 0.263 |
| eGFR < 60 mL/min/1.73 m | 3.01 | (2.44, 3.71) | <.0001 | 1.71 | (1.37,2.14) | <.0001 |
| SBP >140 mmHg | 1.47 | (1.25, 1.72) | <.0001 | |||
| Quartile 1 of LDL-C | Ref | Ref | – | Ref | Ref | – |
| Quartile 2 of LDL-C | 0.92 | (0.75, 1.13) | 0.400 | 1.03 | (0.84, 1.27) | 0.778 |
| Quartile 3 of LDL-C | 0.77 | (0.62, 0.95) | 0.015 | 1.08 | (0.87, 1.35) | 0.475 |
| Quartile 4 of LDL-C | 0.66 | (0.53, 0.83) | 0.000 | 1.01 | (0.8, 1.27) | 0.937 |
| Heart rate >80 bpm | 1.49 | (1.27, 1.73) | <.0001 | 1.31 | (1.12, 1.54) | 0.001 |
| BMI >28 kg/m | 0.84 | (0.67, 1.04) | 0.114 | 0.94 | (0.76, 1.16) | 0.562 |
| LA diameter >40 mm | 1.69 | (1.41, 2.01) | <.0001 | 1.21 | (1, 1.47) | 0.050 |
| Drinking (any) | 0.71 | (0.56, 0.89) | 0.004 | 1.04 | (0.81, 1.33) | 0.761 |
| Smoking (any) | 0.95 | (0.76, 1.18) | 0.618 | |||
| Persistent AF | 1.27 | (1.09, 1.48) | 0.003 | 0.96 | (0.81, 1.14) | 0.634 |
| Medical history | ||||||
| COPD | 1.67 | (0.92, 3.04) | 0.092 | 0.97 | (0.53, 1.77) | 0.917 |
| Hyperthyroidism | 0.91 | (0.29, 2.84) | 0.864 | |||
| Moderate-to-severe mitral regurgitation | 2.04 | (1.59, 2.61) | <.0001 | 1.38 | (1.05, 1.81) | 0.021 |
| Heart failure | 3.42 | (2.92, 4) | <.0001 | 2.22 | (1.87, 2.64) | <.0001 |
| Hypertension | 1.54 | (1.27, 1.88) | <.0001 | 1.04 | (0.84, 1.27) | 0.729 |
| Diabetes mellitus | 1.44 | (1.23, 1.69) | <.0001 | 1.09 | (0.92, 1.28) | 0.331 |
| Previous stroke/TIA/TE | 2.09 | (1.78, 2.46) | <.0001 | 1.59 | (1.34, 1.88) | <.0001 |
| Hyperlipidemia | 0.82 | (0.7, 0.96) | 0.014 | |||
| Vascular disease | 2.19 | (1.84, 2.62) | <.0001 | 1.43 | (1.18, 1.74) | 0.000 |
| Previous bleeding | 1.91 | (1.46, 2.5) | <.0001 | 1.55 | (1.18, 2.04) | 0.002 |
| Use of OAC | 0.62 | (0.52, 0.75) | <.0001 | 0.70 | (0.58, 0.85) | 0.000 |