04 December 2021: Clinical Research
A Pilot Randomized Controlled Trial of Intermittent Theta Burst Stimulation as Stand-Alone Treatment for Post-Stroke Aphasia: Effects on Language and Verbal Functional Magnetic Resonance Imaging (fMRI)
Jane B. Allendorfer 1BCDEF* , Rodolphe Nenert 1BCDE , Jennifer Vannest 2ABCDE , Jerzy P. Szaflarski 13ABCDEFGDOI: 10.12659/MSM.934818
Med Sci Monit 2021; 27:e934818
Table 3 Location and cluster extent of brain regions showing significant differences in fMRI activation patterns between time points (T1, T2, T3) for the verb-generation task (VGT) and verbal paired associates task (VPAT). Peak Montreal Neurologic Institute (MNI) coordinates (x, y, z) and t-value for each brain region are also provided.
| Contrast | Group | Brain regions | Peak MNI coordinates | Peak t-value | Cluster size (mm3) |
|---|---|---|---|---|---|
| VGT: Speech Production/Auditory Processing (“Say Verbs” vs “Think Verbs”)a | |||||
| T1 >T2 | Tx0 | R. Middle Occipital Gyrus extending to R. Fusiform Gyrus, and to L. Calcarine Gyrus and Lingual Gyrus | +28, −95, +16 | −9.63 | 4779 |
| Tx123 | R. Putamen extending to R. Insula, Superior Medial Gyrus, and Anterior Cingulate Cortex | +31, +4, +7 | −4.31 | 6102 | |
| T2 | Tx123 | R. Inferior Temporal Gyrus | +55, +4, −38 | 4.44 | 4050 |
| VGT: Processing Noun-Verb Semantic Associations (“Say Verbs” vs “Repeat Nouns”)b | |||||
| T1 >T2 | Tx0 | R. Calcarine Gyrus extending to L. Cuneus and Middle Occipital Gyrus, and to L. Lingual Gyrus and Superior Occipital Gyrus | +16, −74, +4 | −7.88 | 10,881 |
| R. Putamen extending to R. Anterior Insula | +31, +13, +1 | −9.30 | 5373 | ||
| R. Cerebellum extending to L. Cerebellum | +19, −56, −23 | −7.84 | 3915 | ||
| VPAT: Verbal Encoding (“Generate” vs “Read”)c | |||||
| T1 | Tx0 | R. Precuneus extending to Middle Cingulate Cortex, Paracentral Lobule, and Postcentral Gyrus | +4, −44, +46 | 7.62 | 4239 |
| T1 >T2 | Tx123 | R./L. Anterior Cingulate Cortex | +4, +34, +16 | −4.09 | 3807 |
| T1 | Tx123 | L. Fusiform Gyrus extending to Inferior/Middle Occipital Gyrus | −41, −80, −14 | 6.31 | 3807 |
| L – left; R – right. a For the VGT contrast of “say verbs” vs “think verbs” in Tx0, simulations yielded cluster thresholds of 3699 mm for both T1 vs T2 and T1 vs T3, and 3915 mm for T2 vs T3. For the VGT contrast in Tx123, simulations yielded cluster thresholds of 3375 mm for T1 vs T2, 3618 mm for T2 vs T3, and 3564 mm for T1 vs T3. b For the VGT contrast of “say verbs” vs “repeat nouns” in the Tx0, simulations yielded cluster thresholds of 3213 mm for both T1 vs T2 and T1 vs T3, and 3078 mm for T2 vs T3. For the VGT in the Tx123 group, simulations yielded cluster extent volume thresholds of 3213 mm for T1 vs T2, 3348 mm for T2 vs T3, and 3294 mm for T1 vs T3. c For the VPAT contrast of “generate” vs “read” in the Tx0 group, simulations yielded a critical cluster extent volume thresholds of 3564 mm for T1 vs T2, 4374 mm for T2 vs T3, and 4698 mm for T1 vs T3. For the VPAT contrast in the Tx123 group, simulations yielded cluster thresholds of 3024 mm for T1 vs T2, and 3402 mm for both T2 vs T3 and T1 vs T3. | |||||